Résumé :
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[BDSP. Notice produite par INIST juDRtR0x. Diffusion soumise à autorisation]. Risk factors were examined for subgroups of breast cancer characterized by estrogen receptor (ER) and progesterone receptor (PR) status. Data from the Carolina Breast Cancer Study, a population-based, North Carolina case-control study of 862 breast cancer cases aged 20-74 years diagnosed during 1993-1996 and 790 controls frequency matched on race and age, were obtained by personal interview. ER and PR status was retrieved from medical records (80%) or was determined in the authors'laboratory (11%) but was missing for 9% of cases. The receptor status distribution was as follows : 53% ER+PR+11% ER+PR-8% ER-PR+and 28% ER-PR-Several hormone-related factors were associated with stronger increased risks for ER+PR+than for ER-PR-breast cancer : the elevated odds ratios were strongest for ER+PR+breast cancer among postmenopausal women who had an early age at menarche (odds ratio (OR)=1.6,95% confidence interval (Cl) : 1.0,2.4), nulliparity/late age at first full-term pregnancy (OR=1.7,95% Cl : 0.9,3.2 and OR=1.6,95% CI : 1.0,2.7, respectively), or a high body mass index (OR=1.6,95% Cl : 0.9,3.0) and among pre-/perimenopausal women who had a high waist-hip ratio (OR=1.9,95% CI : 1.2,3.1). In contrast, family history of breast or ovarian cancer and medical radiation exposure to the chest produced higher odds ratios for ER-PR-than for ER+PR+breast cancer, especially among pre-/perimenopausal women.
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