Titre :
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Variation in the interaction between familial and reproductive factors on the risk of breast cancer according to age, menopausal status, and degree of familiality. (2000)
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Auteurs :
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N. Andrieu ;
S.W. DUFFY ;
M. GERBER ;
M.G. LE ;
H.P. LEE ;
Y. LIFANOVA ;
E. LUPORSI ;
T. PREVOST ;
R. Renaud ;
T.E. ROHAN ;
D.G. ZARIDZE ;
Mrc Biostatistics Unit. Institute of Public Health. University Forvie Site. Robinson Way. Cambridge. GBR ;
Unité Inserm 521. Institut Gustave Roussy. Villejuif. FRA
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Type de document :
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Article
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Dans :
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International journal of epidemiology (vol. 29, n° 2, 2000)
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Pagination :
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214-223
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Langues:
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Anglais
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Mots-clés :
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Cancer
;
Sein
;
Homme
;
Femme
;
Age
;
Epidémiologie
;
Facteur risque
;
Ménopause
;
Reproduction
;
Glande mammaire [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST mQR0xSCh. Diffusion soumise à autorisation]. Background Studies have found that reproductive factors might have a variable effect on the occurrence of breast cancer (BC) according to the existence or not of a family history of BC. The effect of a family history of BC on the risk of BC may also vary according to the age at diagnosis and the degree of kinship. This may confound the relation between familial risk and reproductive factors. A combined analysis was performed to study the interaction between familial risk and reproductive factors according to degree of familiality, age at interview and menopausal status. Methods The present analysis included 2948 cases and 4170 controls in seven case-control studies from four countries. The combined relative risks were estimated using a Bayesian random-effects logistic regression model. Results The main effects of reproductive life factors on the risk of BC are in agreement with previous studies. Two-way interactions between subject's age or menopausal status and a family history of BC were not significant. Although the three-way interaction between age, familial risk and parity was not significant, familial risk seemed to be increased slightly for women with high parity compared with women with low parity in the older age group, and seemed to be slightly decreased for women with high parity compared with women with low parity in younger women. (...)
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