Titre :
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Chlamydia pneumoniae serological status is not associated with asthma in children or young adults. (2000)
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Auteurs :
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G.D. MILLS ;
J.P. FAWCETT ;
G.P. HERBISON ;
J.A. LINDEMAN ;
M.R. SEARS
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Type de document :
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Article
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Dans :
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International journal of epidemiology (vol. 29, n° 2, 2000)
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Pagination :
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280-284
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Langues:
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Anglais
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Mots-clés :
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Asthme
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Enfant
;
Homme
;
Jeune adulte
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Epidémiologie
;
Facteur risque
;
Examen sérologique
;
Bactérie
;
Appareil respiratoire [pathologie]
;
Bronchopneumopathie obstructive
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Résumé :
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[BDSP. Notice produite par INIST 7TR0xTR5. Diffusion soumise à autorisation]. Background The factors that cause the allergic sensitization and inflammation in asthma still remain to be clarified. A role for Chlamydia pneumoniae has been suggested although serological studies have produced conflicting findings. This study aims to clarify the relationship between asthmatic variables and C. pneumoniae serological status. Methods A case-control study was undertaken on an asthma-enriched subset from a longitudinal birth cohort. In all, 198 subjects (96 with self-reported asthma) had C. pneumoniae serology (microimmunofluorescence [MIF] IgG, IgA) undertaken at age 11 and age 21 and assessment made in relation to a number of asthma variables. Results The only statistically significant finding was in subjects self-reporting asthma at age 21 who had evidence of lower IgG titres (P=0.046), a finding in the opposite direction to that expected from the hypothesis. Subjects with high IgG titres (>=128) were less likely to have reported ever having asthma ; odds ratio (OR)=0.29, (95% CI : 0.10-0.87). No association existed between symptoms suggestive of asthma in the previous 12 months and either IgG (P=0.127) or IgA (P=0.189) antibody titres at age 21. Likewise, no association was found between symptoms suggestive of asthma in the previous two years and C. pneumoniae IgG antibody titre (P=0.81) at age 11. There was no evidence of an association with any of the other variables examined at either age 11 or age 21. (...)
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