Résumé :
|
[BDSP. Notice produite par INIST lz3LAR0x. Diffusion soumise à autorisation]. Background Atopy may impair ventilatory function, but results are controversial. We assess the association between individual reactivity to allergens and the level of baseline maximal one-second forced expiratory volume (FEV1), by smoking and respiratory symptoms. Methods The 1472 participants (response 44.5%) of the five Spanish areas of the European Community Respiratory Health Survey (ECRHS) who performed respiratory function tests, skin prick tests and/or specific IgE against common aeroallergens (e.g. mites, pets, mould, pollens) are included. Bronchial hyperreactivity (BHR) was measured with a methacholine challenge. Results After adjusting for BHR and smoking, in addition to the other allergens, skin reactivity to Alternaria (-208 ml ; 95% CI : - 451,35) and IgE antibodies against cat (-124 ml ; 95% CI : - 269,21) and Timothy grass (-115 ml, 95% CI : - 190, - 40) were associated with a decrease in FEV1 in females. Among males, skin reactivity to olive showed the strongest association (-111 ml ; 95% CI : - 261,38). The associations were stronger in females. Smoking modifies the association for Alternaria and cat (P for interaction
|