Titre :
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Assessment of the relationship of chronic opisthorchiasis to Epstein-Barr virus infection as well as some cytogenetical and immunological parameters in two comparable Siberian regions. (2000)
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Auteurs :
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E.N. ILYINSKIKH ;
I.N. ILYINSKIKH ;
N.N. ILYINSKIKH ;
T.M. ISAYEVA ;
V.V. NOVITSKIY ;
L.N. URAZOVA ;
Laboratory of Oncovirology. Institute of Oncology. Tomsk. RUS ;
Siberian Medical University. RUS
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 16, n° 11, 2000)
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Pagination :
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993-1002
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Langues:
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Anglais
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Mots-clés :
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Parasitose
;
Infection
;
Virus
;
Examen sérologique
;
Immunoglobuline
;
Epidémiologie
;
Association
;
Incidence
;
Homme
;
Russie
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Résumé :
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[BDSP. Notice produite par INIST-CNRS 9R0xYob5. Diffusion soumise à autorisation]. Previous studies have shown an increase in the frequency of chromosomal abnormalities in the peripheral blood lymphocytes from opisthorchiasis patients. Some evidence suggests that there is an association between chronic opisthorchiasis and certain herpes viruses. To study the relationship of opisthorchiasis to the reactivation of Epstein-Barr virus (EBV) infection as well as the influence of opisthorchis infection on some cytogenetical and immunological parameters, we used the indirect immunofluorescence for measuring some virus specific antibodies, the cytokinesis-block lymphocyte micronucleus assay, and the quantitative immuno-diffusion method for measuring immunoglobulin concentrations in serum. A total of 1,580 people were monitored in two comparable Siberian regions : in the Ob River region which is endemically related to opisthorchiasis caused by Opisthorchis felineus and in the nonendemic control Yenisey River region. There was no significant difference in each of the tested parameters between two uninfected controls from the endemic Ob and nonendemic Yenisey regions. We have found significant difference (p
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