Résumé :
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[BDSP. Notice produite par INIST iR0xK0Z6. Diffusion soumise à autorisation]. Context The effectiveness of dietary modification in reducing low-density lipoprotein cholesterol (LDL-C) levels can be reliably predicted for populations, but not for individuals. Objective To determine whether individual variation in cholesterol response to dietary modification is a familial trait. Design Two-period, outpatient crossover trial conducted from September 1997 to September 1999. Setting and Participants Fifty-six families from the Dallas-Ft Worth, Tex, area with 2 biological parents and at least 2 children aged 5 years or older volunteered ; 46 families (n=92 adults and n=134 children) completed the study. Intervention All families followed two 5-week dietary regimens that included individualized daily dietary prescriptions and emphasized a low-saturated fat diet supplemented with specially manufactured baked goods and spreadable fat. One regimen used butter only and the other used margarine only. Main Outcome Measure Mean LDL-C levels during the last 2 weeks of each dietary period. Results Margarine intake compared with butter intake lowered LDL-C levels 11% in adults (95% confidence interval [Cl], - 13% to - 9%) and 9% in children (95% CI, - 12% to - 6%) (P<. for both adults and children the distribution of individual responses were peaked around mean response. together family membership accounted variability in response>
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