Titre :
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Multiple primaries in pancreatic cancer patients : indicator of a genetic predisposition ? (2000)
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Auteurs :
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Berthold GERDES ;
Detlef-K BARTSCH ;
Peter LANGER ;
Annette RAMASWAMY ;
Anja WILD ;
Andreas ZIEGLER ;
Department of General Surgery. Philipps University of Marburg. Marburg. DEU
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Type de document :
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Article
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Dans :
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International journal of epidemiology (vol. 29, n° 6, 2000)
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Pagination :
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999-1003
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Langues:
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Anglais
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Mots-clés :
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Cancer
;
Pancréas
;
Homme
;
Epidémiologie
;
Facteur risque
;
Appareil digestif [pathologie]
;
Pancréas [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST 3TY0JR0x. Diffusion soumise à autorisation]. Background The genetic basis of several familial cancers including breast and colon cancers has been identified recently. The occurrence of multiple cancers in one individual is also suggestive of a genetic predisposition. To evaluate inherited predisposition in pancreatic cancer we compared the clinical data of pancreatic cancer patients with and without multiple primaries as well as the frequency of malignancies among their relatives. Methods Detailed data on 69 pancreatic cancer patients included survival time and TNM-classification. Index case data were separated into two groups. The first group (group 1} developed only pancreatic cancer during their lifetime, whereas the second group (group 2) developed additional primary tumours. A systematic family history was taken from 59 of these pancreatic cancer patients using a standardized questionnaire. The pancreatic cancers and the multiple primaries of the 59 patients were histologically proven. Results Of the 69 pancreatic cancer patients, 13 (18.8%) had multiple primaries. Neither the clinical data nor the survival data of the index cases revealed differences between the two groups (all nominal P-values>0.05). In the family history study blood relatives developed a malignancy in 51% (24 of 47) of the families in group 1 compared to 75% (9 of 12) in group 2. The risk of relatives in group 2 of developing a malignant tumour was significantly higher (P=0. (...)
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