Résumé :
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[BDSP. Notice produite par INIST n0LqR0xh. Diffusion soumise à autorisation]. Context Although increased intake of grain products has been recommended to prevent cardiovascular disease (CVD), prospective data examining the relation of whole grain intake to risk of ischemic stroke are sparse, especially among women. Objective To examine the hypothesis that higher whole grain intake reduces the risk of ischemic stroke in women. Design, Setting, and Participants A prospective cohort of 75521 US women aged 38 to 63 years without previous diagnosis of diabetes mellitus, coronary heart disease, stroke, or other CVDs in 1984, who completed detailed food frequency questionnaires (FFQs) in 1984,1986,1990, and 1994, and were followed up for 12 years as part of the Nurses'Health Study. Main Outcome Measure Incidence of ischemic stroke, confirmed by medical records, by quintile of whole grain intake according to FFQ responses. Results During 861900 person-years of follow-up, 352 confirmed incident cases of ischemic stroke occurred. We observed an inverse association between whole grain intake and ischemic stroke risk. The age-adjusted relative risks (RRs) from the lowest to highest quintiles of whole grain intake were 1.00 (referent), 0.68 (95% confidence interval [Cl], 0.49-0.94), 0.69 (95% Cl, 0.51-0.95), 0.49 (95% Cl, 0.35-0.69), and 0.57 (95% Cl, 0.42-0.78 ; P=003 for trend). Adjustment for smoking modestly attenuated this association (RR comparing extreme quintiles, 0.64 ; 95% CI, 0.47-0.89). (...)
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