Résumé :
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[BDSP. Notice produite par INIST-CNRS TCR0xa8n. Diffusion soumise ... autorisation]. Findings from several bêta-carotene supplementation trials were unexpected and conflicted with most observational studies. Carotenoids other than p-carotene are found in a variety of fruits and vegetables and may play a role in this important malignancy, but previous findings regarding the five major carotenoids are inconsistent. The authors analyzed the associations between dietary bêta-carotene, bêta-carotene, lutein/zeaxanthin, lycopene, bêta-cryptoxanthin, vitamin A, serum bêta-carotene, and serum retinol and the lung cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of male smokers conducted in southwestern Finland between 1985 and 1993. Of the 27,084 male smokers aged 50-69 years who completed the 276-food item dietary questionnaire at baseline, 1,644 developed lung cancer during up to 14 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. Consumption of fruits and vegetables was associated with a lower lung cancer risk (relative risk=0.73,95% confidence interval : 0.62,0.86, highest vs. lowest quintile). Lower risks of lung cancer were observed for the highest versus the lowest quintiles of lycopene (28%), lutein/zeaxanthin (17%), bêta-cryptoxanthin (15%), total carotenoids (16%), serum bêta-carotene (19%), and serum retinol (27%). These findings suggest that high fruit and vegetable consumption, particularly a diet rich in carotenoids, tomatoes, and tomato-based products, may reduce the risk of lung cancer.
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