Résumé :
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[BDSP. Notice produite par INIST 0m8R0xIH. Diffusion soumise à autorisation]. Increased plasma levels of bêta-thromboglobulin, a platelet activation marker, are observed in coronary artery disease. Urinary albumin excretion, a marker of endothelial cell perturbation, is related to cardiovascular disease in diabetes. To test the value of these markers in predicting forthcoming coronary disease, the relations between urinary excretions of high molecular weight bêta-thromboglobulin (HMW-bêtaTG) and albumin and subsequent coronary disease in a cohort of 15,484 middle-aged women were investigated in a nested case-control study. Baseline questionnaire data and urine samples were available from a breast cancer screening program in Utrecht during 1982-1985. Cases were Utrecht hospital admissions for myocardial infarction (n=50) or angiographically confirmed coronary disease (n=28) from 1982-1985 to 1990-1991. Classifying events occurred a median of 5.1 years after baseline. Controls were a random sample from the cohort, individually case matched for baseline examination date and age, at a 1 : 2 ratio. HMW-bêtaTG/creatinine ratios (ng/mmol, mean standard error) were 5.3 0.3 in cases and 4.7 0.3 in controls ; albumin/creatinine ratios (mg/mmol, median) were, respectively, 0.37 and 0.22.
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