Résumé :
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[BDSP. Notice produite par INIST PfR0x3MD. Diffusion soumise à autorisation]. This is a meta-analysis of occupational exposures to chlorinated hydrocarbon (CHC) solvents and pancreatic cancer, based primarily on studies that addressed exposure directly (agent studies) and secondarily on studies that reported data without verification of individual CHC exposures (job title studies), all of which were listed in databases for the period January 1969 to May 1998. Standardized extraction of data and double-checking of consistency of data extraction by five extractors were done. Simple random models estimated meta-relative risks. Suggestive weak excesses were found for trichloroethylene (meta-relative risk (MRR)=1.24,95% confidence interval (Cl) : 0.79,1.97), polychlorinated biphenyls (MRR=1.37,95% Cl : 0.56,3.31), methylene chloride (MRR=1.42,95% Cl : 0.80,2.53), and vinyl chloride (MRR=1.17,95% Cl : 0.71,1.91) but not for carbon tetrachloride. One study addressed tetrachloroethylene (MRR=3.08,95% Cl : 0.63,8.99) ; another investigated chlorohydrin production (MRR=4.92,95% Cl : 1.58,11.4). Exposure-response meta-analyses for trichloroethylene and methylene chloride failed to reveal trends. Job title studies on metal degreasing and dry cleaning revealed significant MRRs (2.0 and 1.4, respectively). Publication bias was unlikely. Confounding may have remained insufficiently controlled. (...)
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