Résumé :
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[BDSP. Notice produite par INIST R0xqoPsP. Diffusion soumise à autorisation]. Allergic-like reactions to chemical components of foods and medicines may be common. The prevalence of idiosyncratic reactions to aspirin, salicylate, metabisulfite and tartrazine is not known. We used a tertiary referral clinic population to estimate safe exposure doses for epidemiological studies. A 15% decrease in the amount of air expired in one second was defined a positive response. The median effective molar doses of the agents were remarkably similar : metabisulfite 0.19 mM, 34.4 mg [95% confidence interval (CI) 0.14,0.27 mM] ; tartrazine 0.10 M, 55.0 mg (95% CI 0.05,0.21 mM) ; aspirin 0.09 mM, 16.5 mg (95% CI 0.04,0.19 mM) ; and salicylate 0.11 mM, 15.3 mg (95% CI 0.05,0.27mM). Doses to which the most sensitive (5%) and practically all (95%) susceptible persons might respectively respond are : metabisulfite 4.6 mg, 255.8 mg ; tartrazine 3.4 mg, 885.6 mg ; aspirin 0.8 mg, 332.3 mg ; and salicylate 2.6 mg, 89.9 mg. Doses within these ranges can be used in epidemiological studies.
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