Titre :
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CD4+T-cell number at the time of acquired immunodeficiency syndrome. (1995)
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Auteurs :
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J.M.G. TAYLOR ;
J.V. GIORGI ;
J.P. SY ;
B. VISSCHER ;
Univ California. Dep biostatistics. Los Angeles CA. USA
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 141, n° 7, 1995)
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Pagination :
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645-651
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Langues:
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Anglais
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Mots-clés :
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Virose
;
Infection
;
Survie
;
Homme
;
Epidémiologie
;
Maladie autoimmune
;
Sida
|
Résumé :
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[BDSP. Notice produite par INIST FejR0xhZ. Diffusion soumise à autorisation]. In this article, the authors adapt and extend the methodology of Phillips (Phillips et al. J Acquir Immune Defic Syndr 1992 ; 5 : 148-52) to estimate the distribution of CD4+T-cell number at the time of acquired immunodeficiency syndrome (AIDS) and to estimate the correlation between CD4+T-cell number at AIDS and CD4+T-cell number prior to human immunodeficiency virus infection. Using data from the Los Angeles portion of the Multicenter AIDS Cohort Study, the authors find that the median CD4+T-cell count at the time of AIDS is 67 cells/mm3 with a 95% confidence interval of 58-84. The 5th and 95th percentiles of the distribution are 8 and 284, respectively. The authors estimate the correlation between the CD4+T-cell number at the time of AIDS and the CD4+T-cell number prior to human immunodeficiency virus infection to be 0.71 with a 95% confidence interval of 0.21-0.94. This very high correlation is suggestive of biologic hypotheses concerning possible control of the circulating CD4+T-cell number. The high correlation can also be useful in determining when to start prophylactic treatment.
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