Titre :
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Lowered weight gain during pregnancy and risk of neural tube defects among offspring : Fetal origins of health and disease. (2001)
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Auteurs :
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Gary-M SHAW ;
Suzan-L CARMICHAEL ;
Donna-M SCHAFFER ;
Steve SELVIN ;
Karen TODOROFF ;
March of Dimes Birth Defects Foundation. California Birth Defects Monitoring Program. Emeryville. CA. USA
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Type de document :
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Article
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Dans :
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International journal of epidemiology (vol. 30, n° 1, 2001)
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Pagination :
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60-65
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Langues:
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Anglais
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Mots-clés :
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Régime alimentaire
;
Grossesse
;
Mère
;
Prise poids
;
Anencéphalie
;
Spina bifida
;
Epidémiologie
;
Facteur risque
;
Nouveau né
;
Homme
;
Alimentation
;
Système nerveux [pathologie]
;
Maladie congénitale
;
Malformation
;
Système ostéoarticulaire [pathologie]
;
Rachis [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST rkKpOR0x. Diffusion soumise à autorisation]. Background Maternal nutritional factors have been implicated in the complex aetiology of neural tube defects (NTD). We investigated whether the amount of weight a woman gained during pregnancy was associated with her risk of delivering an infant with an NTD. Methods We conducted a population-based case-control study within the cohort of 708 129 live births and fetal deaths occurring in selected California counties in 1989-1991. Face-to-face interviews were conducted with mothers of 538 (88% of eligible) NTD cases (including those electively terminated, stillborn, or liveborn) and with mothers of 539 (88%) non-malformed liveborn controls within an average of 5 months from the term delivery date. Respondent-reported weight gain during pregnancy (kg) was analysed. Risks of infants having NTD were estimated among women who gained= 10kg during >= 38 week gestations. Results Compared to women who gained >= 10kg, an increased risk for NTD offspring was observed among women who gained
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