Titre : | Association of Obesity-related Genetic Variants With Endometrial Cancer Risk : A Report From the Shanghai Endometrial Cancer Genetics Study. (2011) |
Auteurs : | Ryan-J DELAHANTY ; Alicia BEEGHLY-FADIEL ; Yu-Tang GAO ; . HUI CAI ; JING HE (.) : USA. Department of Biostatistics. School of Medicine. Vanderbilt University. Nashville. TN. ; . JIRONG LONG ; . QIUYIN CAI ; . WANQING WEN ; . WEI ZHENG ; Yong-Bing XIANG ; . XIAO OU SHU ; Wang-Hong XU ; Department of Epidemiology. Shanghai Cancer Institute. Shanghai Jiao Tong University. Shanghai. CHN |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 174, n° 10, 2011) |
Pagination : | 1115-1126 |
Langues: | Anglais |
Mots-clés : | Obésité ; Cancer ; Risque cumulé ; Facteur associé ; Association ; Facteur risque ; Risque ; Chine ; Génétique ; Endomètre ; Génome ; Epidémiologie ; Asie |
Résumé : | [BDSP. Notice produite par INIST-CNRS 8nIorR0x. Diffusion soumise à autorisation]. Obesity is a well-established risk factor for endometrial cancer, the most common gynecologic malignancy. Recent genome-wide association studies (GWAS) have identified multiple genetic markers for obesity. The authors evaluated the association of obesity-related single nucleotide polymorphisms (SNPs) with endometrial cancer using GWAS data from their recently completed study, the Shanghai Endometrial Cancer Genetics Study, which comprised 832 endometrial cancer cases and 2,049 controls (1996-2005). Thirty-five SNPs previously associated with obesity or body mass index (BMI ; weight (kg)/height (m) 2) at a minimum significance level of |