Résumé :
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[BDSP. Notice produite par INIST nZP2R0xf. Diffusion soumise à autorisation]. Objective-To examine the hypothesis that the higher rates of coronary heart disease (CHD) in Indians (South Asians) compared with Malays and Chinese is partly attributable to differences in blood concentrations of homocysteine, and related blood concentrations of folate and vitamin B12. Design-Cross sectional study of the general population. Setting-Singapore. Participants-Random sample of 726 fasting subjects aged 30 to 69 years. Main results-Mean plasma total homocysteine concentrations did not show significant ethnic differences ; values were Indians (men 16.2 and women 11.5 mumol/l), Malays (men 15.0 and women 12.5 mumol/l), and Chinese (men 15.3 and women 12.2 mumol/l), Similarly, the proportions with high plasma homocysteine (>14.0 mumol/l) showed no important ethnic differences being, Indians (men 60.0 and women 21.9%), Malays (men 53.9 and women 37.8%), and Chinese (men 56.6 and women 30.6%). Mean plasma folate concentrations were lower in Indians (men 8.7 and women 10.9 nmol/l) and Malays (men 8.5 and women 10.8 nmol/l), than Chinese (men 9.7 and women 13.8 nmol/l), Similarly, the proportions with low plasma folate (
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