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Article
Martin GOGELE ; John ATTIA ; Julian LITTLE ; Cosetta MINELLI ; Cristian PATTARO ; Peter-P PRAMSTALLER ; Ammarin THAKKINSTIAN ; John-R THOMPSON ; Alex YURKIEWICH ; Center for Biomedicine. European Academy of Bozen. Bolzano Eurac Bolzano. ITA ; University of Lübeck. Lübeck. DEU |[BDSP. Notice produite par INIST-CNRS DR0xDpHG. Diffusion soumise à autorisation]. There has been a steep increase in the number of meta-analyses of genome-wide association (GWA) studies aimed at identifying genetic variants with increasingly sm[...]
Article
Paolo BOFFETTA ; Vincent-J COGLIANO ; Stephen-S HECHT ; John-P IOANNIDIS ; Muin-J KHOURY ; Julian LITTLE ; Daniela SEMINARA ; George-Davey Smith ; Duncan-C Thomas ; Paolo VINEIS ; Deborah-M WINN |[BDSP. Notice produite par INIST-CNRS R0xBmnnk. Diffusion soumise à autorisation]. We propose guidelines to evaluate the cumulative evidence of gene-environment (G x E) interactions in the causation of human cancer. Our approach has its roots in[...]
Article
Jessica DENNIS ; Nick BIRKETT ; Julia FREI ; Mihaela GHEORGHE ; Steven HAWKEN ; Daniel KREWSKI ; Julian LITTLE ; MCKEOWN-EYSSEN (Gail) : CAN. Dalla Lana School of Public Health and Department of Nutritional Sciences. University of Toronto. Toronto. ON. ; McLaughlin Centre for Population Health Risk Assessment. University of Ottawa. Ottawa. ON. CAN |[BDSP. Notice produite par INIST-CNRS kR0x78Hm. Diffusion soumise à autorisation]. Background The case-only study, proposed as a design specifically for assessing departure from multiplicative gene-environment and gene-gene interactions, is of c[...]
Article
Isabel Fortier ; Paul-R BURTON ; Dany DOIRON ; Vincent FERRETTI ; Thomas-J HUDSON ; Bartha Maria Knoppers ; Francois L'HEUREUX ; Julian LITTLE ; Ronald-P STOLK ; International Harmonization Initiative. INT ; Public Population Project in Genomics P3G. Montreal. QC. CAN ; Research Institute - McGill University Health Centre. Montreal. PQ. CAN |[BDSP. Notice produite par INIST-CNRS R0xtmr9B. Diffusion soumise à autorisation]. Background Proper understanding of the roles of, and interactions between genetic, lifestyle, environmental and psycho-social factors in determining the risk of d[...]
Article
Acecile-Jw JANSSENS ; Sara BEDROSIAN ; Paolo BOFFETTA ; Siobhan-M DOLAN ; Nicole DOWLING ; Isabel Fortier ; Andrew-N FREEDMAN ; Jeremy-M GRIMSHAW ; Jeffrey GULCHER ; Marta GWINN ; Mark-A HLATKY ; John-Pa IOANNIDIS ; Holly JANES ; Muin-J KHOURY ; Peter KRAFT ; Julian LITTLE ; Stephanie MELILLO ; Christopher-J O'DONNELL ; Michael-J PENCINA ; David RANSOHOFF ; Sheri-D SCHULLY ; Daniela SEMINARA ; Cornelia-M VAN DUIJN ; Deborah-M WINN ; Caroline-F WRIGHT ; Department of Epidemiology. Erasmus University Medical Center. CA Rotterdam. NLD ; Office of Public Health Genomics. Centers for Disease Control and Prevention. Atlanta GA. USA |[BDSP. Notice produite par INIST-CNRS R0xIJk8j. Diffusion soumise à autorisation]. The rapid and continuing progress in gene discovery for complex diseases is fuelling interest in the potential application of genetic risk models for clinical and[...]
Article
Michael WOLFSON ; Paul-R BURTON ; Vincent FERRETTI ; Isabel Fortier ; Bartha Maria Knoppers ; Philippe LAFLAMME ; Julian LITTLE ; John MACLEOD ; Nicholas MASCA ; Geoff ROWE ; Nuala-A SHEEHAN ; Martin-D TOBIN ; Susan-E WALLACE ; Centre of Genomics and Policy. Faculty of Medicine. Department of Human Genetics. McGill University. Montreal. PQ. CAN ; Departments of Health Sciences and Genetics. University of Leicester. Leicester. GBR ; Public Population Project in Genomics. Montreal. PQ. CAN |[BDSP. Notice produite par INIST-CNRS 999BnR0x. Diffusion soumise à autorisation]. Background Contemporary bioscience sometimes demands vast sample sizes and there is often then no choice but to synthesize data across several studies and to unde[...]
Article
Isabel Fortier ; Susan-A ATKINSON ; Catherine BOILEAU ; Marilyn-J BORUGIAN ; Paul-R BURTON ; Rex-L CHISHOLM ; Mylène Deschênes ; Dany DOIRON ; H. ERICH WICHMANN ; Vincent FERRETTI ; John GALLACHER ; Richard-P GALLAGHER ; Andrés GARCIA-MONTERO ; Carol-M HAMILTON ; Jennifer-R HARRIS ; Hans HILLEGE ; Thomas-J HUDSON ; Kristian HVEEM ; Rudolf KAAKS ; Joost-C KEERS ; Bartha Maria Knoppers ; Francois L'HEUREUX ; Geneviève Lachance ; Pamela LINKSTED ; Julian LITTLE ; Jan-Eric LITTON ; Bette LIU ; John MCLAUGHLIN ; Andres METSPALU ; Robin MORTON ; Lyle-J PALMER ; Louise PARKER ; Nancy-L PEDERSEN ; Leena PELTONEN ; Markus PEROLA ; John-D POTTER ; Andrea RENGIFO ; Paula-J ROBSON ; Tim SPROSEN ; Mark Tremblay ; Anne Vilain ; Bruce-Hr WOLFFENBUTTEL ; Department of Health Sciences and Department of Genetics. University of Leicester. Leicester. GBR ; Generation Scotland. University of Edinburgh. Molecular Medicine Centre. Western. General Hospital. Edinburgh. GBR ; Ontario Institute for Cancer Research. MaRs Centre. Toronto. ON. CAN ; Public Population Project in Genomics. Montreal. QC. CAN |[BDSP. Notice produite par INIST-CNRS 9ostR0xm. Diffusion soumise à autorisation]. Background Vast sample sizes are often essential in the quest to disentangle the complex interplay of the genetic, lifestyle, environmental and social factors tha[...]
Article
Muin-J KHOURY ; Jonine-L BERNSTEIN ; Lars BERTRAM ; Paolo BOFFETTA ; Paul-R BURTON ; Adam-S BUTTERWORTH ; Harry CAMPBELL ; Stephen-J CHANOCK ; Anand CHOCKALINGAM ; Siobhan-M DOLAN ; Isabel Fortier ; Helena FURBERG ; Montserrat GARCIA-CLOSAS ; Marta GWINN ; Julian-Pt HIGGINS ; John-Pa IOANNIDIS ; Acecile-Jw JANSSENS ; Julian LITTLE ; Thomas-R O'BRIEN ; James OSTELL ; Ryan-P OWEN ; Roberta-A PAGON ; Timothy-R REBBECK ; Nathaniel ROTHMAN ; Daniela SEMINARA ; Paolo VINEIS ; . WEI YU ; Deborah-M WINN ; Molecular Epidemiology Unit. University of Cambridge. Cambridge. GBR ; Office of Public Health Genomics. National Center for Chronic Disease Prevention and Health Promotion. Centers for Disease Control and Prevention. Atlanta. GA. USA |[BDSP. Notice produite par INIST-CNRS 8kmBtR0x. Diffusion soumise à autorisation]. Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new lo[...]
Article
Paul-R BURTON ; Paul ELLIOTT ; Isabel Fortier ; Anna-L HANSELL ; Muin-J KHOWY ; Julian LITTLE ; Teri-A MANOLIO ; Public Population Project in Genomics. University of Montreal. CAN |[BDSP. Notice produite par INIST-CNRS 9IDR0x8m. Diffusion soumise à autorisation]. Background : Despite earlier doubts, a string of recent successes indicates that if sample sizes are large enough, it is possible-both in theory and in practice-t[...]
Article
Julian LITTLE ; Nick BIRKETT ; Barbara COHEN ; George DAVEY-SMITH ; Isabel Fortier ; Matthew FREEDMAN ; France Gagnon ; Jean GOLDING ; Jeremy GRIMSHAW ; . GUANG YONG ZOU ; Marta GWINN ; Julian-Pt HIGGINS ; Kim HUTCHINGS ; Claire INFANTE-RIVARD ; John-Pa IOANNIDIS ; Candice-Y JOHNSON ; Muin-J KHOURY ; Richard KING ; John MCLAUGHLIN ; David MOHER ; Andrew PATERSON ; Paul SCHEET ; Alex STEWART ; Valerie TAIT ; Cornelia VAN DUIJN ; Erik VON ELM ; George WELLS ; Miriam WIENS ; Robin-E WILLIAMSON ; Maja ZECEVIC ; Department of Epidemiology and Community Medicine. University of Ottawa. Ottawa. ON. CAN |[BDSP. Notice produite par INIST-CNRS 7JER0xrs. Diffusion soumise à autorisation]. Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this inf[...]
Article
John-Pa IOANNIDIS ; David-J BALDING ; Paolo BOFFETTA ; Anand CHOKKALINGAM ; W. DANA FLANDERS ; Siobhan-M DOLAN ; Timothy-M FRAYLING, disc. ; Julian-Pt HIGGINS ; Muin-J KHOURY ; Julian LITTLE ; Mark-I MCCARTHY ; David-H MCDERMOTT ; Thomas-R O'BRIEN ; Grier-P PAGE ; Timothy-R REBBECK ; Daniela SEMINARA ; André-G UITTERLINDEN ; Paolo VINEIS ; Department of Epidemiology and Public Health. Imperial College. London. GBR |[BDSP. Notice produite par INIST-CNRS R0xNSqfj. Diffusion soumise à autorisation]. Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guid[...]
Article
JOHNSON (Candice-Y) : USA. Department of Epidemiology. Rollins School of Public Health. Emory University. Atlanta. ; Julian LITTLE |[BDSP. Notice produite par INIST-CNRS 79R0x9Dp. Diffusion soumise à autorisation]. Background : The ability of folic acid in the periconceptional period to prevent the occurrence of neural tube defects has stimulated tremendous interest in its e[...]
Article
Turning the pump handle : Evolving methods for integrating the evidence on gene-disease association.
Julian-Pt HIGGINS ; Betsy ANAGNOSTELIS ; Molly-S BRAY ; Adam-S BUTTERWORTH ; John DANESH ; Carol DEZATEUX ; John-E GALLACHER ; Marta GWINN ; John-Pa IOANNIDIS ; Muin-J KHOURY ; Sarah-J LEWIS ; Julian LITTLE ; Teri-A MANOLIO ; Cosetta MINELLI ; Paul-D PHAROAH ; Georgia SALANTI ; Simon SANDERSON ; Liam SMEETH ; Lesley-A Smith ; Jonathan-A STERNE ; Emanuela TAIOLI ; John-R THOMPSON ; Simon-G THOMPSON ; Neil WALKER ; Ron-L ZIMMERN ; Department of Hygiene and Epidemiology. University of loannina School of Medicine. Ioannina. GRC ; Department of Public Health and Primary Care. University of Cambridge. Cambridge. GBR ; National Office of Public Health Genomics. Centers for Disease Control and Prevention. Atlanta. GA. USA |[BDSP. Notice produite par INIST-CNRS R0xhaa99. Diffusion soumise à autorisation].
Article
[BDSP. Notice produite par INIST-CNRS R0x3Fawu. Diffusion soumise à autorisation]. BACKGROUND : Most common human diseases are due to complex interactions among multiple genetic variants and environmental risk factors. There is debate over wheth[...]
Article
Linda SHARP ; Julian LITTLE ; University of Aberdeen. Department of Medicine and Therapeutics. Epidemiology Group. Aberdeen Scotland. GBR |[BDSP. Notice produite par INIST-CNRS tR0xtWKL. Diffusion soumise à autorisation]. Epidemiologic and mechanistic evidence suggests that folate is involved in colorectal neoplasia. Some polymorphic genes involved in folate metabolism-methylenetet[...]
