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[BDSP. Notice produite par INIST-CNRS GGIHR0xE. Diffusion soumise à autorisation]. microRNAs (miRNAs) are fundamental to cellular biology. Although only approximately 22 bases long, miRNAs regulate complex processes in health and disease, includ[...]
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Loanna TZOULAKI ; Timothy-Md EBBELS ; Department of Epidemiology and Biostatistics, Imperial College London (London, Royaume-uni) ; Ana VALDES ; Mrc-Phe Centre for Environment and Health, Imperial College London (London, Royaume-uni) ; Paul ELLIOTT ; John-Pa IOANNIDIS |[BDSP. Notice produite par INIST-CNRS GmR0xCps. Diffusion soumise à autorisation]. Metabolomics is the field of "-omics" research concerned with the comprehensive characterization of the small low-molecular-weight metabolites in biological sampl[...]
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[BDSP. Notice produite par INIST-CNRS R0x77I7G. Diffusion soumise à autorisation]. Objectif Analyser les données tirées des essais contrôlés randomisés (ECR) sur la prévention et le contrôle des maladies tropicales négligées (MTN) et identifier [...]
Article
Acecile-Jw JANSSENS ; Sara BEDROSIAN ; Paolo BOFFETTA ; Siobhan-M DOLAN ; Nicole DOWLING ; Isabel Fortier ; Andrew-N FREEDMAN ; Jeremy-M GRIMSHAW ; Jeffrey GULCHER ; Marta GWINN ; Mark-A HLATKY ; John-Pa IOANNIDIS ; Holly JANES ; Muin-J KHOURY ; Peter KRAFT ; Julian LITTLE ; Stephanie MELILLO ; Christopher-J O'DONNELL ; Michael-J PENCINA ; David RANSOHOFF ; Sheri-D SCHULLY ; Daniela SEMINARA ; Cornelia-M VAN DUIJN ; Deborah-M WINN ; Caroline-F WRIGHT ; Department of Epidemiology. Erasmus University Medical Center. CA Rotterdam. NLD ; Office of Public Health Genomics. Centers for Disease Control and Prevention. Atlanta GA. USA |[BDSP. Notice produite par INIST-CNRS R0xIJk8j. Diffusion soumise à autorisation]. The rapid and continuing progress in gene discovery for complex diseases is fuelling interest in the potential application of genetic risk models for clinical and[...]
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Valentina GALLO ; Matthias EGGER ; Peter-B FARMER ; John-Pa IOANNIDIS ; Micheline KIRSCH-VOLDERS ; Giuseppe MATULLO ; Valerie MCCORMACK ; David-H PHILLIPS ; Miquel Porta ; Bernadette SCHOKET ; Ulf STROMBERG ; Roel VERMEULEN ; Paolo VINEIS ; Christopher WILD ; (H.U.G.E.F.). Human Genetics Foundation. Turin. ITA ; International Agency for Research on Cancer (IARC) (Lyon, FRA) |[BDSP. Notice produite par INIST-CNRS AR0xp899. Diffusion soumise à autorisation]. Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological cha[...]
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Kristian THORLUND ; Bodil ALS-NIELSEN ; P.J. DEVEREAUX ; Lise-Lotte GLUUD ; Christian GLUUD ; Gordon GUYATT ; John-Pa IOANNIDIS ; Lehana THABANE ; Jorn WETTERSLEV ; Copenhagen Trial Unit. Center for Clinical Intervention Research. Copenhagen University Hospital. Copenhagen. DNK ; Faculty of Health Sciences. Department of Clinical Epidemiology and Biostatistics. McMaster University. Clarity. Hamilton. ON. CAN |[BDSP. Notice produite par INIST-CNRS 8EGoR0xo. Diffusion soumise à autorisation]. Background : Results from apparently conclusive meta-analyses may be false. A limited number of events from a few small trials and the associated random error may[...]
Article
Muin-J KHOURY ; Jonine-L BERNSTEIN ; Lars BERTRAM ; Paolo BOFFETTA ; Paul-R BURTON ; Adam-S BUTTERWORTH ; Harry CAMPBELL ; Stephen-J CHANOCK ; Anand CHOCKALINGAM ; Siobhan-M DOLAN ; Isabel Fortier ; Helena FURBERG ; Montserrat GARCIA-CLOSAS ; Marta GWINN ; Julian-Pt HIGGINS ; John-Pa IOANNIDIS ; Acecile-Jw JANSSENS ; Julian LITTLE ; Thomas-R O'BRIEN ; James OSTELL ; Ryan-P OWEN ; Roberta-A PAGON ; Timothy-R REBBECK ; Nathaniel ROTHMAN ; Daniela SEMINARA ; Paolo VINEIS ; . WEI YU ; Deborah-M WINN ; Molecular Epidemiology Unit. University of Cambridge. Cambridge. GBR ; Office of Public Health Genomics. National Center for Chronic Disease Prevention and Health Promotion. Centers for Disease Control and Prevention. Atlanta. GA. USA |[BDSP. Notice produite par INIST-CNRS 8kmBtR0x. Diffusion soumise à autorisation]. Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new lo[...]
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Julian LITTLE ; Nick BIRKETT ; Barbara COHEN ; George DAVEY-SMITH ; Isabel Fortier ; Matthew FREEDMAN ; France Gagnon ; Jean GOLDING ; Jeremy GRIMSHAW ; . GUANG YONG ZOU ; Marta GWINN ; Julian-Pt HIGGINS ; Kim HUTCHINGS ; Claire INFANTE-RIVARD ; John-Pa IOANNIDIS ; Candice-Y JOHNSON ; Muin-J KHOURY ; Richard KING ; John MCLAUGHLIN ; David MOHER ; Andrew PATERSON ; Paul SCHEET ; Alex STEWART ; Valerie TAIT ; Cornelia VAN DUIJN ; Erik VON ELM ; George WELLS ; Miriam WIENS ; Robin-E WILLIAMSON ; Maja ZECEVIC ; Department of Epidemiology and Community Medicine. University of Ottawa. Ottawa. ON. CAN |[BDSP. Notice produite par INIST-CNRS 7JER0xrs. Diffusion soumise à autorisation]. Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this inf[...]
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John-Pa IOANNIDIS ; David-J BALDING ; Paolo BOFFETTA ; Anand CHOKKALINGAM ; W. DANA FLANDERS ; Siobhan-M DOLAN ; Timothy-M FRAYLING, disc. ; Julian-Pt HIGGINS ; Muin-J KHOURY ; Julian LITTLE ; Mark-I MCCARTHY ; David-H MCDERMOTT ; Thomas-R O'BRIEN ; Grier-P PAGE ; Timothy-R REBBECK ; Daniela SEMINARA ; André-G UITTERLINDEN ; Paolo VINEIS ; Department of Epidemiology and Public Health. Imperial College. London. GBR |[BDSP. Notice produite par INIST-CNRS R0xNSqfj. Diffusion soumise à autorisation]. Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guid[...]
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Dimitrios-N LATHYRIS ; John-Pa IOANNIDIS ; Thomas-A TRILCALMOS ; Tufts University. School of Medicine. Department of Medicine. Institute for Clinical Research and Health Policy Studies. Boston. MA. USA ; University of loannina. School of Medicine. Department of Hygiene and Epidemiology. Clinical Trials and Evidence-Based Medicine Unit. Ioannina. GRC |[BDSP. Notice produite par INIST-CNRS gR0xrODm. Diffusion soumise à autorisation]. Background : We aimed to evaluate empirically how crossover trial results are analysed in meta-analyses of randomized evidence and whether their results agree wit[...]
Article
Turning the pump handle : Evolving methods for integrating the evidence on gene-disease association.
Julian-Pt HIGGINS ; Betsy ANAGNOSTELIS ; Molly-S BRAY ; Adam-S BUTTERWORTH ; John DANESH ; Carol DEZATEUX ; John-E GALLACHER ; Marta GWINN ; John-Pa IOANNIDIS ; Muin-J KHOURY ; Sarah-J LEWIS ; Julian LITTLE ; Teri-A MANOLIO ; Cosetta MINELLI ; Paul-D PHAROAH ; Georgia SALANTI ; Simon SANDERSON ; Liam SMEETH ; Lesley-A Smith ; Jonathan-A STERNE ; Emanuela TAIOLI ; John-R THOMPSON ; Simon-G THOMPSON ; Neil WALKER ; Ron-L ZIMMERN ; Department of Hygiene and Epidemiology. University of loannina School of Medicine. Ioannina. GRC ; Department of Public Health and Primary Care. University of Cambridge. Cambridge. GBR ; National Office of Public Health Genomics. Centers for Disease Control and Prevention. Atlanta. GA. USA |[BDSP. Notice produite par INIST-CNRS R0xhaa99. Diffusion soumise à autorisation].
Article
John-Pa IOANNIDIS, disc. ; Anne-V BUCHANAN ; David COGGON, disc. ; Stephanie-M FULLERTON ; John Hardy, disc. ; Nancy-Cp LOW, disc. ; Robert-C MILLIKAN, disc. ; Kathleen RIES MERIKANGAS, disc. ; Sharon SCHWARTZ, disc. ; Ezra Susser, disc. ; Douglas-L WEED, disc. ; Kenneth-M WEISS ; Columbia University. Mailman School of Public Health. Department of Epidemiology. New York. USA ; National Institute of Mental Health. National Institutes of Health. Section on Developmental Genetic Epidemiology. Bethesda. MD. USA ; Penn State University. Department of Anthropology. University Park. PA. USA |[BDSP. Notice produite par INIST-CNRS EnJAR0xp. Diffusion soumise à autorisation]. Is the search for the causes of complex disease akin to the alchemist's vain quest for the Philosopher's Stone ? Complex chronic diseases have tremendous public h[...]
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John-Pa IOANNIDIS ; KHOURY (Muin-J) : USA. Office of Genomics and Disease Prevention. Centers for Disease Control and Prevention. Atlanta. GA. ; Thomas-A TRIKALINOS ; Tufts University School of Medicine. Institute for Clinical Research and Health Policy Studies. Boston. MA. USA |[BDSP. Notice produite par INIST-CNRS H0R0xF9H. Diffusion soumise à autorisation]. Accumulated evidence from searching for candidate gene-disease associations of complex diseases can offer some insights as the field moves toward discovery-orient[...]
Article
[BDSP. Notice produite par INIST-CNRS zYR0xlni. Diffusion soumise à autorisation]. Objectif : Cette étude vise à évaluer si les essais contrôlés randomisés effectués en Afrique avec des collaborateurs extérieurs à l'Afrique sont plus étroitement[...]
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John-Pa IOANNIDIS ; James-J GOEDERT ; Thomas-R O'BRIEN ; Philip-S ROSENBERG ; International Meta-analysis of Hiv Host Genetics. INC ; Viral Epidemiology Branch. Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. Rockville. MD. USA |[BDSP. Notice produite par INIST-CNRS aR0x6F59. Diffusion soumise à autorisation]. The authors summarize their experience in the conduct of meta-analysis of individual participants'data (MIPD) with time-to-event analyses in the field of genetic [...]
