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Article
Tauseef-A KHAN ; Mohammad-R ABDOLLAHI ; Yoav BEN-SHLOMO ; Juan-P Casas ; Jackie COOPER ; Ian DAY ; John DEANFIELD ; Ann DONALD ; Shah EBRAHIM ; Luigi FERRUCCI ; Gerda FILLENBAUM ; Gerald-R FOWKES ; Ruth FRIKKE-SCHMIDT ; Tom-R GAUNT ; Grazyna GROMADZKA ; John Hardy ; Bastiaan-T HEIJMANS ; Aroon-D HINGORANI ; Jaroslav-A HUBACEK ; Steve-E HUMPHRIES ; . KAI SUN ; Tomohiro KATSUYA ; Kay-Tee KHAW ; Mika KIVIMAKI ; Meena KUMARI ; Debbie-A LAWLOR ; Mar MATARIN ; James MESCHIA ; Richard MORRIS ; Michael NAILS ; Jackie PRICE ; David PRIETO ; Stephen-S RICH ; . RUTAI HUI ; Manjinder SANDHU ; Tina SHAH ; Andrew SINGLETON ; Arjen-Jc SLOOTER ; Liam SMEETH ; George-Davey Smith ; Johan SUNDSTROM ; Zoltan SZOLNOKI ; Philippa-J TALMUD ; Anne TYBJAERG-HANSEN ; Nicholas WAREHAM ; . WEILI ZHANG ; Peter WHINCUP ; John WHITTAKER ; Bradford WORRALL |[BDSP. Notice produite par INIST-CNRS IDR0xEsI. Diffusion soumise à autorisation]. Background At the APOE gene, encoding apolipoprotein E, genotypes of the epsilon2/epsilon3/epsilon4 alleles associated with higher LDL-cholesterol (LDL-C) levels [...]
Article
Reecha SOFAT ; Gonçalo ABECASIS ; Dominique-C BAAS ; Arthur-A BERGEN ; Shomi-S BHATTACHARYA ; Alan-C BIRD ; Kari-Eh BRANHAM ; Catey BUNCE ; Maria CAROLINA ORTUBE ; Juan-P Casas ; Usha CHAKRAVARTHY ; Li-L CHEN ; Valentina CIPRIANI ; Yvette-P CONLEY ; Angela-J CREE ; Paulus-Tv-m DE JONG ; Robert-E FERRELL ; Astrid FLETCHER ; Lars-G FRITSCHE ; Daniel GIBBS ; Michael-B GORIN ; Helen-L GRIFFITHS ; Aroon-D HINGORANI ; Johanna JAKOBSDOTTIR ; Sharon-A JENKINS ; . KANG ZHANG ; Claudia-N KEILHAUER ; Jane-C KHAN ; Caroline-Cw KLAVER ; Mark LATHROP ; Thierry LEVEILLARD ; Andrew LOTERY ; Samantha-S MANN ; Anthony-T MOORE ; Tune PETO ; Mati RAHU ; Johan-H SELAND ; Tiina SEPP ; Humma SHAHID ; Liam SMEETH ; Gisele SOUBRANE ; Anand SWAROOP ; Laura TOMAZZOLI ; Fotis TOPOUZIS ; Jesus VIOQUE ; Bernhard-Hf Weber ; Andrew-R WEBSTER ; Daniel-E WEEKS ; John WHITTAKER ; John-Rw YATES ; Ian YOUNG ; . YUHONG CHEN ; Sepideh ZAREPARSI |[BDSP. Notice produite par INIST-CNRS R0x9H8m9. Diffusion soumise à autorisation]. Background Variation in the complement factor H gene (CFH) is associated with risk of late age-related macular degeneration (AMD). Previous studies have been case[...]
Article
Spiros-C DENAXAS ; Julie GEORGE ; Harry Hemingway ; Emily HERRETT ; Aroon-D HINGORANI ; KALRA (Dipak) : GBR. Centre for Health Informatics and Multi-professional Education. University College London. London. ; Mika KIVIMAKI ; Anoop-D SHAH ; Liam SMEETH ; TIMMIS (Adam-D) : GBR. National Institute for Health Research Biomedical Research Unit. Barts Health. London. ; Department of Epidemiology and Public Health. Clinical Epidemiology. University College London. London. GBR ; Department of Non-Communicable Disease Epidemiology. London School of Hygiene and Tropical Medicine. London. GBR |[BDSP. Notice produite par INIST-CNRS AR0xqoCl. Diffusion soumise à autorisation]. The goal of cardiovascular disease (CVD) research using linked bespoke studies and electronic health records (CALIBER) is to provide evidence to inform health car[...]
Article
Eleonora STAINES-URIAS ; Juan-P Casas ; Pat DOYLE ; Frank DUDBRIDGE ; Aroon-D HINGORANI ; IOANNIDIS (John-Pa) : GRC. Department of Hygiene and Epidemiology. University of Ioannina School of Medicine. Ioannina. ; KEATING (Brendan-J) : USA. The Institute for Translational Medicine and Therapeutics. School of Medicine. University of Pennsylvania. Philadelphia. PA. ; Maria-C PAEZ ; Norma-C SERRANO ; Centro de Investigaciones Biomedicas. Facultad de Ciencias de la Salud. Universidad Autonoma de Bucaramanga. COL ; Faculty of Epidemiology and Population Health. London School of Hygiene & Tropical Medicine. GBR ; Faculty of Population Health Science. University College London. GBR |[BDSP. Notice produite par INIST-CNRS I97tR0xp. Diffusion soumise à autorisation]. Background Pre-eclampsia is thought to have a polygenic basis, but the identification of susceptibility genes and the quantification of associated risks have been[...]
Article
Rachel-M FREATHY ; George DAVEY SMITH ; Shah EBRAHIM ; Timothy-M FRAYLING ; Andrew-T HATTERSLEY ; Anita HILL ; Aroon-D HINGORANI ; Claus HOLST ; Barbara-J JEFFERIS ; Paul-Cd JOHNSON ; Gbenga-R KAZEEM ; Sofia-Ii KRING ; Debbie-A LAWLOR ; Vincent MOOSER ; Richard-W MORRIS ; Marcus MUNAFO ; Sandosh PADMANABHAN ; Lavinia PATERNOSTER ; Martin PREISIG ; Susan-M RING ; Naveed SATTAR ; Thorkild-Ia SORENSEN ; Federica TOZZI ; Mark-N UPTON ; Peter VOLLENWEIDER ; Gérard WAEBER ; Graham WATT ; Peter-H WHINCUP ; British Heart Foundation Glasgow Cardiovascular Research Centre. Faculty of Medicine. University of Glasgow. Glasgow. GBR ; Department of Internal Medicine. University Hospital Center and University of Lausanne. Lausanne. CHE ; Genetics of Complex Traits. Peninsula College of Medicine and Dentistry. University of Exeter. Exeter. GBR ; Institute of Preventive Medicine. Copenhagen Capital Region. Copenhagen University Hospitals. Copenhagen. DNK ; Peninsula Nihr Clinical Research Facility. Peninsula College of Medicine and Dentistry. University of Exeter. Exeter. GBR ; The Mrc Centre for Causal Analyses in Translational Epidemiology CaiTe Department of Social Medicine. University of Bristol. Bristol. GBR |[BDSP. Notice produite par INIST-CNRS lJR0xoAA. Diffusion soumise à autorisation]. Background Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weig[...]
Article
Gareth-J MCKAY ; Goncalo-R ABECASIS ; Paul-N BAIRD ; Usha CHAKRAVARTHY ; Valentina CIPRIANI ; Shilpa DASARI ; Paulus-Tdv DE JONG ; Michael DEAN ; Sarah ENNIS ; Astrid-E FLETCHER ; Peter-J FRANCIS ; Lars-G FRITSCHE ; Michael-B GORIN ; Robyn-H GUYMER ; Caroline HAYWARD ; Aroon-D HINGORANI ; Lintje HO ; Atsuhiro KANDA ; Claudia-N KEILHAUER ; Caroline-C KLAVER ; Michael-L Klein ; Chia-Ling KUO ; Andrew-J LOTERY ; Anthony-T MOORE ; Anton ORLIN ; Mohammad OTHMAN ; Chris-C PATTERSON ; Inga PETER ; Mati RAHU ; Julie SAWITZKE ; Johanna-M SEDDON ; Johan-H SELAND ; Giuliana SILVESTRI ; Reecha SOFAT ; Gisele SOUBRANE ; Dwight STAMBOLIAN ; Anand SWAROOP ; Laura TOMAZZOLI ; Fotis TOPOUZIS ; Johannes-R VINGERLING ; Jesus VIOQUE ; Bernhard-H Weber ; Andrew-R WEBSTER ; Daniel-E WEEKS ; . WEI CHEN ; Alan-F WRIGHT ; John-R YATES ; Ian-S YOUNG ; Centre for Eye Research Australia. Royal Victorian Eye and Ear Hospital. University of Melbourne. East Melbourne. Victoria. AUS ; Centre for Public Health. Queen's University Belfast. Belfast Northern Ireland. GBR ; Centre for Vision and Vascular Science. Queen's University Belfast. Belfast Northern Ireland. GBR ; Department of Ophthalmology. University of Pennsylvania. Philadelphia. PA. USA ; Institute of Human Genetics. University of Regensburg. Regensburg. DEU ; Macular Degeneration Center. Casey Eye Institute. Oregon Health and Science University. Portland. OR. USA |[BDSP. Notice produite par INIST-CNRS AR0xDAn8. Diffusion soumise à autorisation]. Variation in the apolipoprotein E gene (APOE) has been reported to be associated with longevity in humans. The authors assessed the allelic distribution of APOE i[...]
Article
Tina SHAH ; Juan-P Casas ; Jackie-A COOPER ; John-E DEANFIELD ; Fgerald-R FOWKES ; Aroon-D HINGORANI ; Steve-E HUMPHRIES ; Gordon-D LOWE ; Valerie MCCORMACK ; Ann RUMLEY ; Liam SMEETH ; Reecha SOFAT ; Ioanna TZOULAKI ; Centre for Clinical Pharmacology. University College London. London. GBR |[BDSP. Notice produite par INIST-CNRS 9R0x78H8. Diffusion soumise à autorisation]. Background : Non-uniform reporting of relevant relationships and metrics hampers critical appraisal of the clinical utility of C-reactive protein (CRP) measuremen[...]
Article
Juan-P Casas ; BAUTISTA (Leonelo-E) : USA. Population Health Sciences. University of Wisconsin Medical School. Madison. WI. ; CAVALLERI (Gianpiero-L) : USA. The Institute for Genome Science and Policy. Duke University. Durham. NC. ; Aroon-D HINGORANI ; HUMPHRIES (Steve-E) : GBR. Centre for Cardiovascular Genetics. Department of Medicine. British Heart Foundation Laboratories at University College London. London. ; Liam SMEETH ; University College London. British Heart Foundation Laboratories. Department of Medicine. Centre for Clinical Pharmacology. London. GBR |[BDSP. Notice produite par INIST-CNRS ki9lR0xB. Diffusion soumise à autorisation]. This review examines the association of a subset of endothelial nitric oxide synthase gene (NOS3) polymorphisms (Glu298Asp, intron 4, and - 786T> C) with cardiova[...]
Article
Juan-P Casas ; Leonelo-E BAUTISTA ; Helen-M COLHOUN ; Jackie COOPER ; Giovanni DI MINNO ; Dairena GAFFNEY ; Anders HAMSTEN ; Emma HAWE ; Aroon-D HINGORANI ; Steve-E HUMPHRIES ; Steven-J HUREL ; Irene JUHAN-VAGUE ; Teake KOOISTRA ; Shona LIVINGSTONE ; Maurizio MARGAGLIONE ; Alex-D MCMAHON ; Tom MEADE ; George-J Miller ; Denis-S O'REILLY ; Christopher-J PACKARD ; Naveed SATTAR ; Tina SHAH ; Jeffrey-W STEPHENS ; Elena TREMOLI ; John-S YUDKIN ; Glasgow Royal Infirmary. Department of Pathological Biochemistry. Glasgow. GBR ; Ospedale Casa Sollievo della Sofferenza. Instituto di Ricovero e Cura a Carattere Scientifico. San Giovanni Rotondo. ITA ; University College London. (U.C.L.). Bhf Laboratories. Department of Medicine. Centre for Cardiovascular Genetics. London. GBR ; University College London. (U.C.L.). Bhf Laboratories. Department of Medicine. Centre for Clinical Pharmacology. London. GBR ; University College London. (U.C.L.). Department of Epidemiology. London. GBR |[BDSP. Notice produite par INIST-CNRS R0xk1D4Q. Diffusion soumise à autorisation]. Background : It is unclear wheather the association between C-reactive protein (CRP) and incident coronary events is free from bias and confounding. Individuals h[...]
