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Article
Tauseef-A KHAN ; Mohammad-R ABDOLLAHI ; Yoav BEN-SHLOMO ; Juan-P Casas ; Jackie COOPER ; Ian DAY ; John DEANFIELD ; Ann DONALD ; Shah EBRAHIM ; Luigi FERRUCCI ; Gerda FILLENBAUM ; Gerald-R FOWKES ; Ruth FRIKKE-SCHMIDT ; Tom-R GAUNT ; Grazyna GROMADZKA ; John Hardy ; Bastiaan-T HEIJMANS ; Aroon-D HINGORANI ; Jaroslav-A HUBACEK ; Steve-E HUMPHRIES ; . KAI SUN ; Tomohiro KATSUYA ; Kay-Tee KHAW ; Mika KIVIMAKI ; Meena KUMARI ; Debbie-A LAWLOR ; Mar MATARIN ; James MESCHIA ; Richard MORRIS ; Michael NAILS ; Jackie PRICE ; David PRIETO ; Stephen-S RICH ; . RUTAI HUI ; Manjinder SANDHU ; Tina SHAH ; Andrew SINGLETON ; Arjen-Jc SLOOTER ; Liam SMEETH ; George-Davey Smith ; Johan SUNDSTROM ; Zoltan SZOLNOKI ; Philippa-J TALMUD ; Anne TYBJAERG-HANSEN ; Nicholas WAREHAM ; . WEILI ZHANG ; Peter WHINCUP ; John WHITTAKER ; Bradford WORRALL |[BDSP. Notice produite par INIST-CNRS IDR0xEsI. Diffusion soumise à autorisation]. Background At the APOE gene, encoding apolipoprotein E, genotypes of the epsilon2/epsilon3/epsilon4 alleles associated with higher LDL-cholesterol (LDL-C) levels [...]
Article
Reecha SOFAT ; Gonçalo ABECASIS ; Dominique-C BAAS ; Arthur-A BERGEN ; Shomi-S BHATTACHARYA ; Alan-C BIRD ; Kari-Eh BRANHAM ; Catey BUNCE ; Maria CAROLINA ORTUBE ; Juan-P Casas ; Usha CHAKRAVARTHY ; Li-L CHEN ; Valentina CIPRIANI ; Yvette-P CONLEY ; Angela-J CREE ; Paulus-Tv-m DE JONG ; Robert-E FERRELL ; Astrid FLETCHER ; Lars-G FRITSCHE ; Daniel GIBBS ; Michael-B GORIN ; Helen-L GRIFFITHS ; Aroon-D HINGORANI ; Johanna JAKOBSDOTTIR ; Sharon-A JENKINS ; . KANG ZHANG ; Claudia-N KEILHAUER ; Jane-C KHAN ; Caroline-Cw KLAVER ; Mark LATHROP ; Thierry LEVEILLARD ; Andrew LOTERY ; Samantha-S MANN ; Anthony-T MOORE ; Tune PETO ; Mati RAHU ; Johan-H SELAND ; Tiina SEPP ; Humma SHAHID ; Liam SMEETH ; Gisele SOUBRANE ; Anand SWAROOP ; Laura TOMAZZOLI ; Fotis TOPOUZIS ; Jesus VIOQUE ; Bernhard-Hf Weber ; Andrew-R WEBSTER ; Daniel-E WEEKS ; John WHITTAKER ; John-Rw YATES ; Ian YOUNG ; . YUHONG CHEN ; Sepideh ZAREPARSI |[BDSP. Notice produite par INIST-CNRS R0x9H8m9. Diffusion soumise à autorisation]. Background Variation in the complement factor H gene (CFH) is associated with risk of late age-related macular degeneration (AMD). Previous studies have been case[...]
Article
Spiros-C DENAXAS ; Julie GEORGE ; Harry Hemingway ; Emily HERRETT ; Aroon-D HINGORANI ; KALRA (Dipak) : GBR. Centre for Health Informatics and Multi-professional Education. University College London. London. ; Mika KIVIMAKI ; Anoop-D SHAH ; Liam SMEETH ; TIMMIS (Adam-D) : GBR. National Institute for Health Research Biomedical Research Unit. Barts Health. London. ; Department of Epidemiology and Public Health. Clinical Epidemiology. University College London. London. GBR ; Department of Non-Communicable Disease Epidemiology. London School of Hygiene and Tropical Medicine. London. GBR |[BDSP. Notice produite par INIST-CNRS AR0xqoCl. Diffusion soumise à autorisation]. The goal of cardiovascular disease (CVD) research using linked bespoke studies and electronic health records (CALIBER) is to provide evidence to inform health car[...]
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[BDSP. Notice produite par INIST-CNRS HR0xpm8B. Diffusion soumise à autorisation]. Objectives. We estimated the collective burden of mortality from autoimmune diseases among females in the United Kingdom and the effects of death certificate codi[...]
Article
SOMERS (Emily-C) : USA. Division of Rheumatology. University of Michigan. Ann Arbor. MI. ; Andrew-J HALL ; Liam SMEETH ; Sara-L Thomas |[BDSP. Notice produite par INIST-CNRS I7R0x8o8. Diffusion soumise à autorisation]. Limited evidence suggests that autoimmune diseases tend to co-occur, although data are needed to determine whether individuals with an existing autoimmune disorde[...]
Article
Tina SHAH ; Juan-P Casas ; Jackie-A COOPER ; John-E DEANFIELD ; Fgerald-R FOWKES ; Aroon-D HINGORANI ; Steve-E HUMPHRIES ; Gordon-D LOWE ; Valerie MCCORMACK ; Ann RUMLEY ; Liam SMEETH ; Reecha SOFAT ; Ioanna TZOULAKI ; Centre for Clinical Pharmacology. University College London. London. GBR |[BDSP. Notice produite par INIST-CNRS 9R0x78H8. Diffusion soumise à autorisation]. Background : Non-uniform reporting of relevant relationships and metrics hampers critical appraisal of the clinical utility of C-reactive protein (CRP) measuremen[...]
Article
Turning the pump handle : Evolving methods for integrating the evidence on gene-disease association.
Julian-Pt HIGGINS ; Betsy ANAGNOSTELIS ; Molly-S BRAY ; Adam-S BUTTERWORTH ; John DANESH ; Carol DEZATEUX ; John-E GALLACHER ; Marta GWINN ; John-Pa IOANNIDIS ; Muin-J KHOURY ; Sarah-J LEWIS ; Julian LITTLE ; Teri-A MANOLIO ; Cosetta MINELLI ; Paul-D PHAROAH ; Georgia SALANTI ; Simon SANDERSON ; Liam SMEETH ; Lesley-A Smith ; Jonathan-A STERNE ; Emanuela TAIOLI ; John-R THOMPSON ; Simon-G THOMPSON ; Neil WALKER ; Ron-L ZIMMERN ; Department of Hygiene and Epidemiology. University of loannina School of Medicine. Ioannina. GRC ; Department of Public Health and Primary Care. University of Cambridge. Cambridge. GBR ; National Office of Public Health Genomics. Centers for Disease Control and Prevention. Atlanta. GA. USA |[BDSP. Notice produite par INIST-CNRS R0xhaa99. Diffusion soumise à autorisation].
Article
Juan-P Casas ; BAUTISTA (Leonelo-E) : USA. Population Health Sciences. University of Wisconsin Medical School. Madison. WI. ; CAVALLERI (Gianpiero-L) : USA. The Institute for Genome Science and Policy. Duke University. Durham. NC. ; Aroon-D HINGORANI ; HUMPHRIES (Steve-E) : GBR. Centre for Cardiovascular Genetics. Department of Medicine. British Heart Foundation Laboratories at University College London. London. ; Liam SMEETH ; University College London. British Heart Foundation Laboratories. Department of Medicine. Centre for Clinical Pharmacology. London. GBR |[BDSP. Notice produite par INIST-CNRS ki9lR0xB. Diffusion soumise à autorisation]. This review examines the association of a subset of endothelial nitric oxide synthase gene (NOS3) polymorphisms (Glu298Asp, intron 4, and - 786T> C) with cardiova[...]
Article
Dorothea NITSCH ; Bianca-L DESTAVOLA ; David-A LEON ; Mariam MOLOKHIA ; Liam SMEETH ; John-C WHITTAKER |[BDSP. Notice produite par INIST-CNRS iI6m6R0x. Diffusion soumise à autorisation]. "Mendelian randomization" refers to the random assortment of genes transferred from parent to offspring at the time of gamete formation. This process has been com[...]
Article
Frank DE VRIES ; N.K. ARDEN, disc. ; Cyrus COOPER ; Corinne DE VRIES ; Ian DOUGLAS, disc. ; C.J. EDWARDS, disc. ; Richard HUBBARD, disc. ; Bert LEUFKENS ; Christoph-R Meier, disc. ; Liam SMEETH, disc. ; Tjeerd-Pieter VAN STAA ; Southampton General Hospital. Department of Rheumatology. Southampton. GBR ; University of Southampton. Southampton General Hospital. Medical Research Council Environmental Epidemiology Unit. Southampton. GBR ; University of Utrecht. Utrecht Institute for Pharmaceutical Sciences. Utrecht. NLD |[BDSP. Notice produite par INIST-CNRS CpV6bR0x. Diffusion soumise à autorisation]. Background : Two recent case-control studies by Meier et al. and van Staa et al. used the UK General Practice Research Database (GPRD) to examine the association [...]
Article
Yuji NISHIWAKI ; Elizabeth BREEZE ; Christopher-J BULPITT ; Astrid-E FLETCHER ; Ruth Peters ; Liam SMEETH ; University of London. Imperial College of Science Technology and Medicine. Faculty of Medicine. Section of Care of the Elderly. London. GBR ; University of London. London School of Hygiene and Tropical Medicine. Centre for Ageing and Public Health. London. GBR |[BDSP. Notice produite par INIST-CNRS IR0xz1Ih. Diffusion soumise à autorisation]. The authors studied the validity of the Clock-Drawing Test (CDT) in comparison with the Mini-Mental State Examination (MMSE) and the association between the CDT a[...]
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Richard HUBBARD ; Paddy FARRINGTON ; Liam SMEETH ; Chris Smith ; Anne TATTERSFIELD ; Division of Respiratory Medicine. University of Nottingham. Nottingham City Hospital. Nottingham. GBR |[BDSP. Notice produite par INIST-CNRS bzwTxR0x. Diffusion soumise à autorisation]. The use of tricyclic antidepressants is associated with an increased risk of hip fracture. Despite a better side effect profile, this adverse effect has also been[...]
