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Article
Isabel Fortier ; Paul-R BURTON ; Dany DOIRON ; Vincent FERRETTI ; Thomas-J HUDSON ; Bartha Maria Knoppers ; Francois L'HEUREUX ; Julian LITTLE ; Ronald-P STOLK ; International Harmonization Initiative. INT ; Public Population Project in Genomics P3G. Montreal. QC. CAN ; Research Institute - McGill University Health Centre. Montreal. PQ. CAN |[BDSP. Notice produite par INIST-CNRS R0xtmr9B. Diffusion soumise à autorisation]. Background Proper understanding of the roles of, and interactions between genetic, lifestyle, environmental and psycho-social factors in determining the risk of d[...]
Article
[BDSP. Notice produite par INIST-CNRS nIAR0x8F. Diffusion soumise à autorisation]. Background In a recent paper by Homer et al. (Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping[...]
Article
Michael WOLFSON ; Paul-R BURTON ; Vincent FERRETTI ; Isabel Fortier ; Bartha Maria Knoppers ; Philippe LAFLAMME ; Julian LITTLE ; John MACLEOD ; Nicholas MASCA ; Geoff ROWE ; Nuala-A SHEEHAN ; Martin-D TOBIN ; Susan-E WALLACE ; Centre of Genomics and Policy. Faculty of Medicine. Department of Human Genetics. McGill University. Montreal. PQ. CAN ; Departments of Health Sciences and Genetics. University of Leicester. Leicester. GBR ; Public Population Project in Genomics. Montreal. PQ. CAN |[BDSP. Notice produite par INIST-CNRS 999BnR0x. Diffusion soumise à autorisation]. Background Contemporary bioscience sometimes demands vast sample sizes and there is often then no choice but to synthesize data across several studies and to unde[...]
Article
Isabel Fortier ; Susan-A ATKINSON ; Catherine BOILEAU ; Marilyn-J BORUGIAN ; Paul-R BURTON ; Rex-L CHISHOLM ; Mylène Deschênes ; Dany DOIRON ; H. ERICH WICHMANN ; Vincent FERRETTI ; John GALLACHER ; Richard-P GALLAGHER ; Andrés GARCIA-MONTERO ; Carol-M HAMILTON ; Jennifer-R HARRIS ; Hans HILLEGE ; Thomas-J HUDSON ; Kristian HVEEM ; Rudolf KAAKS ; Joost-C KEERS ; Bartha Maria Knoppers ; Francois L'HEUREUX ; Geneviève Lachance ; Pamela LINKSTED ; Julian LITTLE ; Jan-Eric LITTON ; Bette LIU ; John MCLAUGHLIN ; Andres METSPALU ; Robin MORTON ; Lyle-J PALMER ; Louise PARKER ; Nancy-L PEDERSEN ; Leena PELTONEN ; Markus PEROLA ; John-D POTTER ; Andrea RENGIFO ; Paula-J ROBSON ; Tim SPROSEN ; Mark Tremblay ; Anne Vilain ; Bruce-Hr WOLFFENBUTTEL ; Department of Health Sciences and Department of Genetics. University of Leicester. Leicester. GBR ; Generation Scotland. University of Edinburgh. Molecular Medicine Centre. Western. General Hospital. Edinburgh. GBR ; Ontario Institute for Cancer Research. MaRs Centre. Toronto. ON. CAN ; Public Population Project in Genomics. Montreal. QC. CAN |[BDSP. Notice produite par INIST-CNRS 9ostR0xm. Diffusion soumise à autorisation]. Background Vast sample sizes are often essential in the quest to disentangle the complex interplay of the genetic, lifestyle, environmental and social factors tha[...]
Article
Muin-J KHOURY ; Jonine-L BERNSTEIN ; Lars BERTRAM ; Paolo BOFFETTA ; Paul-R BURTON ; Adam-S BUTTERWORTH ; Harry CAMPBELL ; Stephen-J CHANOCK ; Anand CHOCKALINGAM ; Siobhan-M DOLAN ; Isabel Fortier ; Helena FURBERG ; Montserrat GARCIA-CLOSAS ; Marta GWINN ; Julian-Pt HIGGINS ; John-Pa IOANNIDIS ; Acecile-Jw JANSSENS ; Julian LITTLE ; Thomas-R O'BRIEN ; James OSTELL ; Ryan-P OWEN ; Roberta-A PAGON ; Timothy-R REBBECK ; Nathaniel ROTHMAN ; Daniela SEMINARA ; Paolo VINEIS ; . WEI YU ; Deborah-M WINN ; Molecular Epidemiology Unit. University of Cambridge. Cambridge. GBR ; Office of Public Health Genomics. National Center for Chronic Disease Prevention and Health Promotion. Centers for Disease Control and Prevention. Atlanta. GA. USA |[BDSP. Notice produite par INIST-CNRS 8kmBtR0x. Diffusion soumise à autorisation]. Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new lo[...]
Article
Paul-R BURTON ; Paul ELLIOTT ; Isabel Fortier ; Anna-L HANSELL ; Muin-J KHOWY ; Julian LITTLE ; Teri-A MANOLIO ; Public Population Project in Genomics. University of Montreal. CAN |[BDSP. Notice produite par INIST-CNRS 9IDR0x8m. Diffusion soumise à autorisation]. Background : Despite earlier doubts, a string of recent successes indicates that if sample sizes are large enough, it is possible-both in theory and in practice-t[...]
Article
Tom-M PALMER ; Paul-R BURTON ; Nuala-A SHEEHAN ; John-R THOMPSON ; Martin-D TOBIN ; Department of Health Sciences. University of Leicester. GBR ; Departments of Health Sciences and Genetics. University of Leicester. GBR |[BDSP. Notice produite par INIST-CNRS 7mB7DR0x. Diffusion soumise à autorisation]. Background : Mendelian randomization uses a carefully selected gene as an instrumental-variable (IV) to test or estimate an association between a phenotype and a [...]
Article
Martin-D TOBIN ; Peter BRAUND ; Paul-R BURTON ; Cother HAJAT ; Mika KAHONEN ; Terho LEHTIMAKI ; Rami LEHTINEN ; Peter-W MACFARLANE ; Gandre NG ; Tuomo NIEMINEN ; Nilesh-J SAMANI ; Maciej TOMASZEWSKI ; Jari VIIK ; Department of Cardiovascular Sciences. University of Leicester. Glenfield Hospital. GBR ; Department of Clinical Physiology. Tampere University Hospital and Medical School. University of Tampere. FIN ; Department of Genetics. University of Leicester. GBR ; Department of Health Sciences. University of Leicester. GBR |[BDSP. Notice produite par INIST-CNRS Dk79DR0x. Diffusion soumise à autorisation]. Background : A longer heart-rate corrected QT interval (QTc) is associated with increased risk of ventricular arrhythmias. Women have longer resting QTc and are m[...]
Article
Mary DIXON-WOODS ; ASHCROFT (Richard-E) : GBR. Queen Mary. University of London. ; Paul-R BURTON ; Clare-J JACKSON ; Joëlle Kivits ; Nilesh-J SAMANI ; Martin-D TOBIN |[BDSP. Notice produite par INIST-CNRS XsR0xHz5. Diffusion soumise à autorisation]. Although the need to obtain "informed" consent is institutionalised as a principle of ethical practice in research, there is persistent evidence that the meanings[...]
Article
M.B. KATAN ; Paul BRENNAN ; Paul-R BURTON ; David-V CONTI ; Shah EBRAHIM ; Richard GRAY ; Bernard KEAVNEY ; Cosetta MINELLI ; George-Davey Smith ; Duncan-C Thomas ; John-R THOMPSON ; Martin-D TOBIN ; Keith WHEATLEY ; University of Birmingham Clinical Trials Unit. Birmingham. GBR ; University of Leicester. Department of Epidemiology and Public Health. Leicester. GBR ; University of Southern California. Department of Preventive Medicine. Los Angeles. CA. USA |[BDSP. Notice produite par INIST-CNRS ZGVR0xk9. Diffusion soumise à autorisation].
