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A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children.

Maurine-R HOBBS ; Nicholas-M ANSTEY ; Jennifer BOOTH ; Hilary COON ; Donald-L Granger ; Simon KARIUKI ; Altaf-L LAL ; Marc-C LEVESQUE ; Esther-D MWAIKAMBO ; Bernard-L NAHLEN ; Ann POLE ; Jacquelin-M ROBERTS ; Ariana-N TKACHUK ; Venkatachalam UDHAYAKUMAR ; J-Brice WEINBERG ; Department of internal Medicine. University of Utah and Va Medical Centers. Salt Lake City. UT. USA ; Department of Medicine. Va and Duke University Medical Centers. Durham. NC. USA |

Dans Lancet (The) (vol. 360, n° 9344, 2002)

[BDSP. Notice produite par INIST-CNRS 65XiR0xh. Diffusion soumise à autorisation]. Background Nitric oxide (NO) is a mediator of immunity to malaria, and genetic polymorphisms in the promoter of the inducible NO synthase gene (NOS2) could modula[...]

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