| Titre : | Associations of plant-based dietary patterns with gut microbiota profiles and metabolic health in Korean adults: a cross-sectional study |
| Auteurs : | Nayeon Kwon ; Ecole des hautes études en santé publique (EHESP) (Rennes, FRA) |
| Type de document : | Mémoire |
| Année de publication : | 2025 |
| Description : | 35p. |
| Langues: | Anglais |
| Classement : | MPH/ (Mémoires MPH à partir de 2024) |
| Mots-clés : | Régime alimentaire ; Aliment ; Produit végétal ; Plante ; Végétarisme ; Intestin ; Métabolisme ; Corée du Sud |
| Résumé : |
Background: Plant-based diets are increasingly adopted worldwide, yet not all plant-based foods confer equal metabolic advantages. Plant-based diet indices (PDIs), including healthy PDI (hPDI) and unhealthy PDI (uPDI), differentiate plant-based food quality, but their relationships with gut microbiota and metabolic health remain unclear.
Objective: This study investigated associations between PDIs, gut microbial diversity, and metabolic markers in Korean adults, examining enterotype- and age-specific differences. Methods: We analyzed data from 336 Korean adults aged 18-60 years across two cross-sectional studies (2018, 2021). Dietary intake was assessed using a 106-item semi-quantitative food frequency questionnaire. Gut microbiota data were obtained through 16S rRNA gene sequencing. Associations were analyzed using general linear regression models adjusted for confounding variables, with further stratified by enterotype and age. Results: Higher PDI and hPDI scores were positively associated with gut microbial α-diversity (Chao1 and Shannon indices), while uPDI showed inverse associations. Higher α-diversity correlated with favorable metabolic markers, including lower glucose and triglyceride levels and higher HDL-cholesterol (HDL-C). Notably, uPDI was negatively associated with HDL-C levels (effect size = -0.35 ± 0.11 per unit increase, p = 0.001), mediated through alterations in bacterial genera including Lactobacillus, Catenibacterium. The uPDI-HDL-C relationship was particularly pronounced in participants under 40 years or Bacteroides-dominant enterotype, but not in older or Prevotella-dominant enterotype groups. Conclusions: Plant-based food quality determines metabolic benefits through alterations in gut microbiota. Age-dependent and enterotype-specific responses highlight the potential for personalized nutrition approaches considering gut microbial profiles and demographic factors. These findings support refining current dietary guidelines to incorporate plant-based food quality and individual microbial, thereby enhancing their effectiveness in promoting health benefits. |
| Diplôme : | Master MPH of public health |
| Plan de classement simplifié : | Master of Public Health - master international de Santé Publique (MPH) |
| En ligne : | https://documentation.ehesp.fr/memoires/2025/mph/nayeon_kwon.pdf |
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