| Titre : | Identification of Hydroxychloroquine-Induced Retinal Toxicity in Lupus Patients Using Rule-Based Natural Language Processing on French Electronic Health Record Data |
| Auteurs : | Solène Bossart ; Ecole des hautes études en santé publique (EHESP) (Rennes, FRA) |
| Type de document : | Mémoire |
| Année de publication : | 2025 |
| Description : | 36p. |
| Langues: | Anglais |
| Classement : | MPH/ (Mémoires MPH à partir de 2024) |
| Mots-clés : | Lupus érythémateux disséminé ; Hydroxychloroquine ; Oeil [pathologie] ; Toxicité ; Surveillance ; Dossier médical informatisé |
| Résumé : | Hydroxychloroquine (HCQ) is a cornerstone of lupus treatment but carries a risk of retinal toxicity with prolonged use. Monitoring for hydroxychloroquine-induced maculopathy is essential, yet documentation of related follow-up and treatment decisions is often embedded in unstructured electronic health records (EHRs), limiting systematic analysis. This project aimed to develop and validate a rule-based natural language processing (NLP) pipeline to extract clinically relevant information on HCQ exposure, maculopathy, ophthalmology follow-up, and treatment discontinuation from French EHR data. |
| Diplôme : | Master MPH of public health |
| Plan de classement simplifié : | Master of Public Health - master international de Santé Publique (MPH) |
| En ligne : | https://documentation.ehesp.fr/memoires/2025/mph/solene_bossart.pdf |
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