| Titre : | Factors associated with the development of chronic P. falciparum infection in the Sahel |
| Auteurs : | Eric P. Twomey ; Ecole des hautes études en santé publique (EHESP) (Rennes, FRA) |
| Type de document : | Mémoire |
| Année de publication : | 2024 |
| Description : | 44p. / tabl., graph. |
| Langues: | Anglais |
| Classement : | MPH/ (Mémoires MPH à partir de 2024) |
| Mots-clés : | Paludisme ; Sénégal ; Mali ; Moustique ; Vecteur ; Lutte antivectorielle ; Prophylaxie |
| Résumé : | Plasmodium infections range from severe disease to asymptomatic cases, with untreated infections potentially persisting for months or years. Asymptomatic individuals, forming a "reservoir," contribute substantially to malaria transmission. This study focuses on the factors influencing the persistence of Plasmodium falciparum infections in the Sahel region, considering sociodemographic, clinical, and environmental variables. Data from the Malaria Asymptomatic Reservoir in the Sahel (MARS) Study, an open cohort study in eight villages across Senegal and Mali, were used. ( ) This study highlights the importance of targeted interventions to reduce the malaria reservoir, particularly during the late dry season when persistence is highest. The identification of "superhosts" suggests the need for further research into genetic and immunological profiles. Localized public health strategies are essential to address transmission hotspots. Seasonal malaria chemoprevention and other interventions have shown efficacy and should be expanded. Continuous monitoring and treatment of asymptomatic carriers are crucial to disrupt the transmission cycle and prevent malaria reintroduction. Future efforts should focus on enhancing localized control measures, improving healthcare accessibility, and maintaining rigorous surveillance to achieve sustainable malaria eradication in the Sahel. (R.A.) |
| Diplôme : | Master MPH of public health |
| Plan de classement simplifié : | Master of Public Health - master international de Santé Publique (MPH) |
| En ligne : | https://documentation.ehesp.fr/memoires/2024/mph/eric_phillip_twomey.pdf |
Documents numériques (1)
 P._Falciparum_Infection URL |