| Titre : | Hormonal exposure and walking speed in women in general population. The CONSTANCES study |
| Auteurs : | Aude Laetitia Ndoadoumgue |
| Type de document : | Mémoire |
| Année de publication : | 2019 |
| Description : | 27+XXIXp. / ann., tabl., graph. |
| Langues: | Anglais |
| Classement : | MPH19/ (Master EHESP International master of public health - MPH) |
| Mots-clés : | Facteur risque ; Hormone ; Femme ; Motricité ; Exposition ; Ménopause ; Vitesse ; Cohorte ; Enquête cohorte |
| Résumé : | Background: Ageing is characterized by a physiological decline in motor functions associated with an increased risk of disability, hospitalization and death. There is however, significant individual heterogeneity in the evolution of the motor function. There has been a decline in functional capacity of women after menopause but the influence of hormonal exposure on walking speed (WS) remains poorly investigated. Methods: The analysis focuses on women 45 years and above recruited in the CONSTANCES cohort study in whom a WS test was performed at inclusion. The association of WS with characteristics of reproductive life and use of exogenous hormones were evaluated cross-sectionally using mixed linear and multinomial logistic regressions models. Results: The analysis sample consisted of 24557 women. The average WS was 173. 1 cm/s. Among all women, age at menarche, number of children and age at first pregnancy were positively associated with WS (β for 1 year= 0.34; 95% CI: 0.15; 0.53, p < 0.001, β per child = 0.84; 95% CI: 0.45; 1.24, p < 0.001, β for 1 year= 0.24; 95% CI: 0.16; 0.32, p < 0.001, for age of menarche, number of children and age at first pregnancy, respectively). On the other hand, menopausal status and use of oral contraceptive pills did not influence walking speed. In menopaused women, similar associations were found for age at puberty, parity and age at first pregnancy. However, age at menopause, type of menopause, duration of reproductive life span, time since onset of menopause and post-menopausal hormonal treatment did not influence WS. Conclusion: This analysis suggests the existence of hormonal determinants of WS in women over 45 years of age. It would appear that being exposure as late as possible in teenage years and to higher oestrogen concentrations later in adult life may be beneficial on the motor function. These results will have to be confirmed in subsequent studies. (R.A.) |
| Diplôme : | Master MPH of public health |
| Plan de classement simplifié : | Master of Public Health - master international de Santé Public (MPH) |
| En ligne : | http://documentation.ehesp.fr/memoires/2019/mph/Aude%20Laetitia%20NDOADOUMGUE.pdf |
Exemplaires (1)
| Code-barres | Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|---|
| 098058 | MPH19/0001 | Mémoire | Rennes | Magasin | Empruntable Disponible |
Documents numériques (1)
 MPH/ndoadoumgue URL |