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Résumé :
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[BDSP. Notice produite par INIST-CNRS DCAR0xED. Diffusion soumise à autorisation]. We performed a meta-analysis of the association of transforming growth factor a gene (TGFA) polymorphisms with the risk of cleft lip with or without cleft palate (CL/P) or cleft palate (CP). In total, data from 29 studies were pooled for the following 3 polymorphisms : TGFA/Taql, TGFA/BamHI, and TGFA/Rasl in the TGFA gene. A fixed-effects or random-effects model was used to calculate the pooled odds ratios based on the results from the heterogeneity tests. A significantly increased CL/P or CP risk was observed in persons carrying a C2 allele at the Taql polymorphism (odds ratio (OR)=1.70,95% confidence interval (Cl) : 1.41,2.05) compared with those with a C1 allele (OR=1.57,95% Cl : 1.23,2.01). For the TGFA/BamHI polymorphism, carriers of the minor A1 allele had an estimated relative decrease in CL/P risk (OR=0.44,95% Cl : 0.30,0.64). These associations remained significant when only high-quality studies were included. However, no significant association was observed between the TGFA/Rasl variant and CL/P risk. In summary, this meta-analysis provided a robust estimate of the positive association of the TGFA/Taql polymorphism with both CL/P and CP and suggests that persons with an A1 allele may have a markedly decreased risk of CL/P.
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