| Titre : | Neonatal Bilirubin Levels and Childhood Asthma in the US Collaborative Perinatal Project, 1959-1965 (2013) |
| Auteurs : | . LISU HUANG ; . YIXIAO BAO ; Moe-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Jiao Tong University School of Medicine (Shanghai, Chine) ; . ZONGLI XU ; Department of Pediatrics, Shanghai Jiao Tong University School of Medicine (Shanghai, Chine) ; . XIAOPING LEI ; . YAN CHEN ; . YONGJUN ZHANG ; . JUN ZHANG |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 178, n° 12, 2013) |
| Pagination : | 1691-1697 |
| Langues: | Anglais |
| Mots-clés : | Asthme ; Nouveau né ; Bilirubine ; Enfant ; Exposition ; Epidémiologie ; Thérapeutique ; Homme ; Amérique ; Bronchopneumopathie obstructive ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 7pFkR0xD. Diffusion soumise à autorisation]. Evidence shows that asthma originates in early life. Studies have found that phototherapy and/or neonatal jaundice may be associated with asthma. We investigated the association between neonatal bilirubin levels and childhood asthma without phototherapy intervention in the Collaborative Perinatal Project, a multicenter prospective cohort study conducted in the United States from 1959 to 1965. A total of 54,795 livebirths were included, and 40,063 children were followed up until 7 years of age or older. Total serum bilirubin (TSB) levels were examined at 48 hours postpartum in newborns with birthweights of 2,250 g or more. Information on asthma and other diseases through age 7 years was summarized and confirmed by a group of pediatricians and child neurologists. Among 28,807 term infants, the overall prevalence of asthma was 5.26%. Risks of asthma increased with both maximum TSB levels and TSB levels at 48 hours postpartum (Pfor trend<0.01). Neonatal maximum TSB levels greater than 15 mg/dL were associated with a 61% increase in the risk of childhood asthma (odds ratio=1.61,95% confidence interval : 1.04,2.08) after adjustment for confounders. In this prospective cohort study of infants born at a time when phototherapy was unavailable, neonatal hyperbilirubinemia was associated with an increased risk of childhood asthma. |
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