| Titre : | Bayesian Sample Size Determination for Case-Control Studies When Exposure May be Misclassified (2013) |
| Auteurs : | Lawrence JOSEPH ; Division of Clinical Epidemiology, McGill University Health Centre (Montreal, Canada) ; Patrick BELISLE |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 178, n° 11) |
| Pagination : | 1673-1679 |
| Langues: | Anglais |
| Mots-clés : | Enquête cas témoin ; Epidémiologie ; Exposition |
| Résumé : | [BDSP. Notice produite par INIST-CNRS IpC9R0xp. Diffusion soumise à autorisation]. Odds ratios are frequently used for estimating the effect of an exposure on the probability of disease in case-control studies. In planning such studies, methods for sample size determination are required to ensure sufficient accuracy in estimating odds ratios once the data are collected. Often, the exposure used in epidemiologic studies is not perfectly ascertained. This can arise from recall bias, the use of a proxy exposure measurement, uncertain work exposure history, and laboratory or other errors. The resulting misclassification can have large impacts on the accuracy and precision of estimators, and specialized estimation techniques have been developed to adjust for these biases. However, much less work has been done to account for the anticipated decrease in the precision of estimators at the design stage. Here, we develop methods for sample size determination for odds ratios in the presence of exposure misclassification by using several interval-based Bayesian criteria. By using a series of prototypical examples, we compare sample size requirements after adjustment for misclassification with those required when this problem is ignored. We illustrate the methods by planning a case-control study of the effect of late introduction of peanut to the diet of children to the subsequent development of peanut allergy. |
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