| Titre : | Associations of Personal and Family Preeclampsia History With the Risk of Early - Intermediate-and Late - Onset Preeclampsia (2013) |
| Auteurs : | Heather-A BOYD ; Department of Epidemiology Research, Statens Serum Institut (Copenhagen, Danemark) ; Hassaan TAHIR ; Jan WOHLFAHRT ; Mads MELBYE |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 178, n° 11) |
| Pagination : | 1611-1619 |
| Langues: | Anglais |
| Mots-clés : | Risque cumulé ; Facteur associé ; Association ; Histoire familiale ; Famille ; Facteur risque ; Risque ; Changement ; Récidive ; Epidémiologie ; Toxémie gravidique |
| Résumé : | [BDSP. Notice produite par INIST-CNRS HBJER0xJ. Diffusion soumise à autorisation]. Preeclampsia encompasses multiple conditions of varying severity. We examined the recurrence and familial aggregation of preeclampsia by timing of onset, which is a marker for severity. We ascertained personal and family histories of preeclampsia for women who delivered live singletons in Denmark in 1978-2008 (almost 1.4 million pregnancies). Using log-linear binomial regression, we estimated risk ratios for the associations between personal and family histories of preeclampsia and the risk of early-onset (before 34 weeks of gestation, which is typically the most severe), intermediate-onset (at 34-36 weeks of gestation), and late-onset (after 36 weeks of gestation) preeclampsia. Previous early-intermediate-or late-onset preeclampsia increased the risk of recurrent preeclampsia with the same timing of onset 25.2 times (95% confidence interval (Cl) : 21.8,29.1), 19.7 times (95% Cl : 17.0,22.8), and 10.3 times (95% Cl : 9.85,10.9), respectively, compared with having no such history. Preeclampsia in a woman's family was associated with a 24% - 163% increase in preeclampsia risk, with the strongest associations for early-and intermediate-onset preeclampsia in female relatives. Preeclampsia in the man's family did not affect a woman's risk of early-onset preeclampsia and was only weakly associated with her risks of intermediate-and late-onset preeclampsia. Early-onset preeclampsia appears to have the largest genetic component, whereas environmental factors likely contribute most to late-onset preeclampsia. The role of paternal genes in the etiology of preeclampsia appears to be limited. |
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