| Titre : | Dynamics of Pneumococcal Transmission in Vaccine-Naive Children and Their HIV-infected or HIV-uninfected Mothers During the First 2 Years of Life (2013) |
| Auteurs : | Tinevimbo SHIRI ; Department of Science and Technology, University of the Witwatersrand (Johannesburg, Afrique du Sud) ; Kari AURANEN ; Medical Research Council Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand (Johannesburg, Afrique du Sud) ; Marta-C NUNES ; Peter-V ADRIAN ; National Institute for Communicable Diseases, National Health Laboratory Service (Sandringham, Afrique du Sud) ; Nadia VAN NIEKERK ; Linda DE GOUVEIA ; Anne VON GOTTBERG ; Keith-P KLUGMAN ; Shabir-A MADHI |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 178, n° 11) |
| Pagination : | 1629-1637 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Prévention santé ; Enfant ; VIH ; Mère ; Exposition ; Epidémiologie ; Virose ; Infection ; Streptococcie ; Bactériose ; Bactérie ; Homme ; Rétrovirus ; Virus ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 88nq7R0x. Diffusion soumise à autorisation]. Pneumococcal vaccine-naive mother-child dyads in South Africa had nasopharyngeal swabs taken 9 times within the first 2 years of the children's lives between January 2007 and May 2009. To quantify the strength of the association of serotype-specific carriage in mother-child dyads, a stochastic transmission model was fitted to the data. Children were more susceptible to individual serotypes included in the 7-valent pneumococcal conjugate vaccine (PCV7) transmitted by their mothers than vice versa ; however, children infected their mothers with these serotypes more frequently than mothers infected children. The child-to-mother steady-state forces of pneumococcal acquisition were between 0.36 and 3.29 (per 1,000 days) compared with 0.06-0.51 for mother-to-child transmission. Although children of mothers infected with human immunodeficiency virus were more often exposed to PCV7 serotypes by their mothers, their risk of acquisition remained low compared with the risk of child-to-mother transmission. Mothers acquired pneumococci at lower rates (per 1,000 days) from unmeasured exposure within families and in the wider community (range, 0.12-1.69 per 1,000 days) than did children (range, 1.10-5.21 per 1,000 days). Pneumococcal immunization of young children is expected to have an indirect effect of reducing PCV7 serotype maternal colonization and possibly disease even in settings such as ours, in which there is a high prevalence of human immunodeficiency virus-infected mothers. |
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