| Titre : | Allergies and Risk of Pancreatic Cancer : A Pooled Analysis From the Pancreatic Cancer Case-Control Consortium (2013) |
| Auteurs : | Sara-H OLSON ; Meier HSU ; Pancreatic Cancer Case-Control Consortium ; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center (New York NY, Etats-Unis) ; Jaya-M SATAGOPAN ; Patrick MAISONNEUVE ; Division of Cancer Epidemiology and Genetics, National Cancer Institute (Bethesda MD, Etats-Unis) ; Department of Epidemiology, Mario Negri Institute for Pharmacological Research (Milan, Italie) ; Debra-T SILVERMAN ; Ersilia LUCENTEFORTE ; Struttura Operativa Complessa di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico (Aviano PN, Italie) ; Department of Epidemiology and Biostatistics, San Francisco (San Francisco CA, Etats-Unis) ; Kristin-E ANDERSON ; Division of Epidemiology and Community Health, University of Minnesota (Minneapolis MN, Etats-Unis) ; Ayelet BORGIDA ; Paige-M BRACCI ; Department of Medicine, Memorial Sloan-Kettering Cancer Center (New York NY, Etats-Unis) ; Hbas BUENO-DE-MESQUITA ; Michelle COTTERCHIO ; . QI DAI ; Eric-J DUELL ; Elizabeth-H FONTHAM ; Steven GALLINGER ; Elizabeth-A HOLLY ; Bu-Tian JI ; Robert-C KURTZ ; Carlo LA VECCHIA ; Albert-B LOWENFELS ; Brian LUCKETT ; Emmy LUDWIG ; Gloria-M PETERSEN ; Jerry POLESEL ; Daniela SEMINARA ; Lori STRAYER ; Renato TALAMINI |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 178, n° 5, 2013) |
| Pagination : | 691-700 |
| Langues: | Anglais |
| Mots-clés : | Allergie ; Facteur risque ; Risque ; Enquête cas témoin ; Epidémiologie ; Hypersensibilité ; Immunopathologie ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 8R0xJoAr. Diffusion soumise à autorisation]. In order to quantify the risk of pancreatic cancer associated with history of any allergy and specific allergies, to investigate differences in the association with risk according to age, gender, smoking status, or body mass index, and to study the influence of age at onset, we pooled data from 10 case-control studies. In total, there were 3,567 cases and 9,145 controls. Study-specific odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression adjusted for age, gender, smoking status, and body mass index. Between-study heterogeneity was assessed by using the Cochran Q statistic. Study-specific odds ratios were pooled by using a random-effects model. The odds ratio for any allergy was 0.79 (95% confidence interval (CI) : 0.62,1.00) with heterogeneity among studies (P<0.001). Heterogeneity was attributable to one study ; with that study excluded, the pooled odds ratio was 0.73 (95% CI : 0.64,0.84) (Pheterogeneity=0.23). Hay fever (odds ratio=0.74,95% CI : 0.56,0.96) and allergy to animals (odds ratio=0.62,95% CI : 0.41,0.94) were related to lower risk, while there was no statistically significant association with other allergies or asthma. There were no major differences among subgroups defined by age, gender, smoking status, or body mass index. Older age at onset of allergies was slightly more protective than earlier age. |
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