| Titre : | Prediction of Cardiovascular Disease Mortality by Proteinuria and Reduced Kidney Function : Pooled Analysis of 39,000 Individuals From 7 Cohort Studies in Japan (2013) |
| Auteurs : | Masaharu NAGATA ; Epoch-Japan Research Group (Japon) ; Toshiharu NINOMIYA ; Department of Environmental Medicine, Kyushu University (Fukuoka, Japon) ; Yutaka KIYOHARA ; Department of Medicine and Clinical Science, Kyushu University (Fukuoka, Japon) ; Yoshitaka Murakami ; Fujiko IRIE ; Department of Health Science, Shiga University of Medical Science (Otsu, Japon) ; Toshimi SAIRENCHI ; Katsuyuki MIURA ; Tomonori OKAMURA ; Hirotsugu UESHIMA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 178, n° 1, Juillet 2013) |
| Pagination : | 1-11 |
| Langues: | Anglais |
| Mots-clés : | Protéinurie ; Cardiopathie coronaire ; Insuffisance rénale ; Homme ; Japon ; Epidémiologie ; Asie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS GAnR0xlF. Diffusion soumise à autorisation]. There are limited studies addressing whether proteinuria and estimated glomerular filtration rate (eGFR) are independently associated with cardiovascular disease in Asia. Using data from 7 prospective cohorts recruited between 1980 and 1994 in Japan, we assessed the influence of proteinuria (>=1+on dipstick) and reduced eGFR on the risk of cardiovascular disease mortality in 39,405 participants (40-89 years) without kidney failure. During a 10.1-year follow-up, 1,927 subjects died from cardiovascular disease. Proteinuria was associated with a 1.75-fold (95% confidence interval (Cl) : 1.44,2.11) increased risk of cardiovascular disease mortality after adjustment for potential confounding factors. Additionally, the multivariate-adjusted hazard ratio of cardiovascular disease mortality increased linearly with lower eGFR levels (Ptrend<0.001) : Subjects with eGFR of<45 mL/minute/1.73 m2 had a 2.22-fold (95% Cl : 1.60,3.07) greater risk of cardiovascular disease mortality than those with eGFR of>=90 mL/minute/1.73 m2. Subjects with both proteinuria and eGFR of<45 mL/minute/1.73 m2 had a 4.05-fold (95% Cl : 2.55,6.43) higher risk of cardiovascular disease mortality compared with those with neither of these risk factors. There was no evidence of interaction in the relationship between proteinuria and lower eGFR (Pinteraction=0.77). The present results suggest that proteinuria and lower eGFR are independent risk factors for cardiovascular disease mortality in the Japanese population. |
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