| Titre : | Chicago Healthy Aging Study : Objectives and Design (2013) |
| Auteurs : | Amber PIRZADA ; Department of Preventive Medicine, Northwestern University (Chicago IL, Etats-Unis) ; Kathryn REID ; Daniel KIM ; Department of Neurology, Northwestern University (Chicago IL, Etats-Unis) ; Daniel-B GARSIDE ; Brandon LU ; Thanh-Huyen-t VU ; Donald M. Lloyd-Jones ; Phyllis ZEE ; . KIANG LIU ; Jeremiah STAMLER ; Martha-L DAVIGLUS |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 178, n° 4, 2013) |
| Pagination : | 635-644 |
| Langues: | Anglais |
| Mots-clés : | Personne âgée ; Vieillissement ; Epidémiologie ; Facteur risque ; Amérique ; Homme ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0x99jHp. Diffusion soumise à autorisation]. Investigators in the Chicago Healthy Aging Study (CHAS) reexamined 1,395 surviving participants aged 65-84 years (28% women) from the Chicago Heart Association Detection Project in Industry (CHA) 1967-1973 cohort whose cardiovascular disease (CVD) risk profiles were originally ascertained at ages 25-44 years. CHAS investigators reexamined 421 participants who were low-risk (LR) at baseline and 974 participants who were non-LR at baseline. LR was defined as having favorable levels of 4 major CVD risk factors : serum total cholesterol level<200 mg/dL and no use of cholesterol-lowering medication ; blood pressure<=120/<=80 mm Hg and no use of antihypertensive medication ; no current smoking ; and no history of diabetes or heart attack. While the potential of LR status in overcoming the CVD epidemic is being recognized, the long-term association of LR with objectively measured health in older age has not been examined. It is hypothesized that persons who were LR in 1967-1973 and have survived to older age will have less clinical and subclinical CVD, lower levels of inflammatory markers, and better physical performance/functioning and sleep quality. Here we describe the rationale, objectives, design, and implementation of this longitudinal epidemiologic study, compare baseline and follow-up characteristics of participants and nonparticipants, and highlight the feasibility of reexamining study participants after an extended period postbaseline with minimal interim contact. |
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