| Titre : | Risk Factors for Specific Histopathological Types of Postmenopausal Breast Cancer in the NIH-AARP Diet and Health Study (2013) |
| Auteurs : | Sarah-J NYANTE ; Division of Cancer Epidemiology and Genetics, National Cancer Institute (Rockville MD, Etats-Unis) ; Cher-M DALLAL ; Gretchen-L GIERACH ; Yikyung PARK ; Albert-R HOLLENBECK ; Louise-A BRINTON |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 178, n° 3, Août 2013) |
| Pagination : | 359-371 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Anatomopathologie ; Femme ; Sein ; Régime alimentaire ; Epidémiologie ; Homme ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xC7mDA. Diffusion soumise à autorisation]. Risk factor associations for rare breast cancer variants are often imprecise, obscuring differences between tumor types. To clarify differences, we examined risk factors for 5 histological types of breast cancer in the National Institutes of Health-AARP Diet and Health Study. Risk factor information was self-reported. We followed 192,076 postmenopausal women aged 50-71 years from 1995-1996 through 2006. During that time period, 5,334 ductal, 836 lobular, 639 mixed ductal-lobular, 216 mucinous, and 132 tubular breast cancers were diagnosed. Hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards regression. Heterogeneity was evaluated using case-only logistic regression. The strongest differences were for menopausal hormone therapy (Pheterogeneity<0.01) and age at first birth (Pheterogeneity<0.01). Risk of tubular cancer in relation to current menopausal hormone therapy (for current use vs. never use, hazard ratio (HR)=4.39,95% confidence interval (CI) : 2.77,6.96) was several times stronger than risk of other histological types (range of HRs, 1.39-1.75). Older age at first birth was unassociated with risk of mucinous (for>=30 years vs. 20-24 years, HR=0.62,95% CI : 0.27,1.42) or tubular (HR=1.08,95% CI : 0.51,2.29) tumors, in contrast to clear positive associations with lobular (HR=1.82,95% CI : 1.39,2.37) and mixed ductal-lobular (HR=1.87,95% CI : 1.39,2.51) tumors. Differing associations for hormonal factors and mucinous and tubular cancers suggest etiologies distinct from those of common breast cancers. |
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