| Titre : | The Association of Plasma Lactate With Incident Cardiovascular Outcomes : The ARIC Study (2013) |
| Auteurs : | Kunihiro MATSUSHITA ; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health (Baltimore MD, Etats-Unis) ; Emma-K Williams ; Division of General Internal Medicine, Johns Hopkins University (Baltimore MD, Etats-Unis) ; Morgana-L MONGRAW-CHAFFIN ; Josef CORESH ; Department of Medicine, Baylor College of Medicine and Methdodist DeBakey Heart and Vascular Center (Houston TX, Etats-Unis) ; Maria-Ines SCHMIDT ; Frederick-L BRANCATI ; Ron-C HOOGEVEEN ; Christie-M BALLANTYNE ; Jhunter YOUNG |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 178, n° 3, Août 2013) |
| Pagination : | 401-409 |
| Langues: | Anglais |
| Mots-clés : | Artériosclérose ; Insuffisance cardiaque ; Association ; Plasma sanguin ; Incidence ; Pronostic ; Epidémiologie ; Amérique ; Cardiopathie ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xso898. Diffusion soumise à autorisation]. We examined the association of plasma lactate at rest, a marker of oxidative capacity, with incident cardiovascular outcomes in 10,006 participants in the Atherosclerosis Risk in Communities (ARIC) Study visit 4 (1996-1998). We used Cox proportional-hazards models to estimate hazard ratios of incident coronary heart disease, stroke, heart failure, and all-cause mortality by quartiles of plasma lactate (Q1,<=5.3 mg/dL ; Q2,5.4-6.6 ; Q3,6.7-8.6 ; and Q4>=8.7). During a median follow-up time of 10.7 years, there were 1,105 coronary heart disease cases, 379 stroke cases, 820 heart failure cases, and 1,408 deaths. A significant graded relation between lactate level and cardiovascular events was observed in the demographically adjusted model (all P for trend<0.001). After further adjustment for traditional and other potential confounders, the association remained significant for heart failure (Q4 vs. Q1 : hazard ratio (HR)=1.35,95% confidence interval (CI) : 1.07,1.71) and all-cause mortality (HR=1.27,95% CI : 1.07,1.51) (P for trend<0.02 for these outcomes) but not for coronary heart disease (HR=1.02,95% CI : 0.84,1.24) and stroke (HR=1.26,95% CI : 0.91,1.75). The results for heart failure were robust across multiple subgroups, after further adjustment for N-terminal pro-B-type natriuretic peptide and after exclusion of participants with incident heart failure within 3 years. The independent associations of plasma lactate with heart failure and all-cause mortality suggest an important role for low resting oxidative capacity. |
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