| Titre : | Environmental Exposure to Metals and Children's Growth to Age 5 Years : A Prospective Cohort Study (2013) |
| Auteurs : | Renee-M GARDNER ; Institute of Environmental Medicine, Karolinska Institutet (Stockholm, Suède) ; Maria KIPPLER ; Fahmida TOFAIL ; International Centre for Diarrhoeal Disease Research (Bangladesh Dhaka, Bangladesh) ; Matteo BOTTAI ; Jena HAMADANI ; Margaretha GRANDER ; Barbro NERMELL ; Brita PALM ; Kathleen-M RASMUSSEN ; Marie VAHTER |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 177, n° 12, 2013) |
| Pagination : | 1356-1367 |
| Langues: | Anglais |
| Mots-clés : | Santé environnementale ; Environnement ; Métal ; Enfant ; Croissance ; Enfant 2 5 ans ; Etude prospective ; Arsenic ; Taille corporelle ; Poids corporel ; Cadmium ; Exposition ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 88R0xrts. Diffusion soumise à autorisation]. In this prospective cohort study, based on 1,505 mother-infant pairs in rural Bangladesh, we evaluated the associations between early-life exposure to arsenic, cadmium, and lead, assessed via concentrations in maternal and child urine, and children's weights and heights up to age 5 years, during the period 2001-2009. Concurrent and prenatal exposures were evaluated using linear regression analysis, while longitudinal exposure was assessed using mixed-effects linear regression. An inverse association was found between children's weight and height, age-adjusted z scores, and growth velocity at age 5 years and concurrent exposure to cadmium and arsenic. In the longitudinal analysis, multivariable-adjusted attributable differences in children's weight at age 5 years were - 0.33 kg (95% confidence interval (CI) : - 0.60, - 0.06) for high (>=95th percentile) arsenic exposure and - 0.57 kg (95% CI : - 0.88, - 0.26) for high cadmium exposure, in comparison with children with the lowest exposure (<=5th percentile). Multivariable-adjusted attributable differences in height were - 0.50 cm (95% CI : - 1.20,0.21) for high arsenic exposure and - 1.6 cm (95% CI : - 2.4, - 0.77) for high cadmium exposure. The associations were apparent primarily among girls. The negative effects on children's growth at age 5 years attributable to arsenic and cadmium were of similar magnitude to the difference between girls and boys in terms of weight (-0.67 kg, 95% CI : - 0.82, - 0.53) and height (-1.3 cm, 95% CI : - 1.7, - 0.89). |
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