| Titre : | Are Women Who Smoke at Higher Risk for Lung Cancer Than Men Who Smoke ? (2013) |
| Auteurs : | Sara DE MATTEIS ; Division of Cancer Epidemiology and Genetics, National Cancer Institute (Bethesda MD, Etats-Unis) ; Dario CONSONNI ; Unit of Epidemiology Department of Preventive Medicine Fondazione Irccs (C.A.'G.R.A.N.D.A.), Maggiore Policlinico (Milan, Italie) ; Angela-C PESATORI ; Andrew-W BERGEN ; Department of Clinical Sciences and Community Health, Università degli Studi di Milano (Milan, Italie) ; Pier-Alberto BERTAZZI ; Neil-E CAPORASO ; Jay-H LUBIN ; Sholom WACHOLDER ; Maria-Teresa LANDI |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 177, n° 7, Avril 2013) |
| Pagination : | 601-612 |
| Langues: | Anglais |
| Mots-clés : | Tabagisme ; Femme ; Enquête cas témoin ; Epidémiologie ; Sexe ; Etude comparée ; Tabac ; Homme ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS lHR0xBrp. Diffusion soumise à autorisation]. Worldwide lung cancer incidence is decreasing or leveling off among men, but rising among women. Sex differences in associations of tobacco carcinogens with lung cancer risk have been hypothesized, but the epidemiologic evidence is conflicting. We tested sex-smoking interaction in association with lung cancer risk within a population-based case-control study, the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study (Lombardy, Italy, 2002-2005). Detailed lifetime smoking histories were collected by personal interview in 2,100 cases with incident lung cancer and 2,120 controls. Odds ratios and 95% confidence intervals for pack-years of cigarette smoking were estimated by logistic regression, adjusted for age, residence area, and time since quitting smoking. To assess sex-smoking interaction, we compared the slopes of odds ratios for logarithm of pack-years in a model for men and women combined. Overall, the slope for pack-years was steeper in men (odds ratio for female-smoking interaction=0.39,95% confidence interval : 0.24,0.62 ; P<0.0001) ; after restriction to ever smokers, the difference in slopes was much smaller (odds ratio for interaction=0.63,95% confidence interval : 0.29,1.37 ; P=0.24). Similar results were found by histological type. Results were unchanged when additional confounders were evaluated (e.g., tobacco type, inhalation depth, Fagerström-assessed nicotine dependence). These findings do not support a higher female susceptibility to tobacco-related lung cancer. |
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