| Titre : | Seasonal Variation in 25-Hydroxyvitamin D Concentrations in the Cardiovascular Health Study. (2011) |
| Auteurs : | SHOBEN (Abigail-B) : USA. Division of Biostatistics. College of Public Health. Ohio State University. Columbus. OH. ; Ian-H DE BOER ; HOOFNAGLE (Andrew-N) : USA. Department of Laboratory Medicine. University of Washington. Seattle. WA. ; Bryan KESTENBAUM ; Gregory Levin ; Bruce-M PSATY ; David-S SISCOVICK ; Cardiovascular Health Research Unit. Departments of Medicine and Epidemiology. University of Washington. Seattle. WA. USA ; Kidney Research Institute. Division of Nephrology. Departments of Medicine and Epidemiology. University of Washington. Seattle. WA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 174, n° 12, 2011) |
| Pagination : | 1363-1372 |
| Langues: | Anglais |
| Mots-clés : | Variation saisonnière ; Concentration ; Appareil cardiovasculaire ; Phosphatase alcaline ; Saison ; Vitamine D ; Epidémiologie ; Enzyme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 7pEq8R0x. Diffusion soumise à autorisation]. Low circulating concentrations of 25-hydroxyvitamin D (25 (OH) D) are associated with adverse health outcomes in diverse populations. However, 25 (OH) D concentrations vary seasonally with varying exposure to sunlight, so single measurements may poorly reflect long-term 25 (OH) D exposure. The authors investigated cyclical trends in average serum 25 (OH) D concentrations among 2,298 individuals enrolled in the Cardiovascular Health Study of community-based older adults (1992-1993). A sinusoidal model closely approximated observed 25 (OH) D concentrations and fit the data significantly better than did a mean model (P <0.0001). The mean annual 25 (OH) D concentration was 25.1 ng/mL (95 % confidence interval : 24.7,25.5), and the mean peak-trough difference was 9.6 ng/mL (95 % confidence interval : 8.5,10.7). Male sex, higher latitude of study site, and greater physical activity levels were associated with larger peak-trough difference in 25 (OH) D concentration (each P <0.05). Serum concentrations of intact parathyroid hormone and bone-specific alkaline phosphatase also varied in a sinusoidal fashion (P <0.0001), inversely to 25 (OH) D. In conclusion, serum 25 (OH) D varies in a sinusoidal manner, with large seasonal differences relative to mean concentration and laboratory evidence of biologic sequelae. Single 25 (OH) D measurements might not capture overall vitamin D status, and the extent of misclassification could vary by demographic and behavioral factors. Accounting for collection time may reduce bias in research studies and improve decision-making in clinical care. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact