| Titre : | Body Size in Early Life and Adult Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3. (2011) |
| Auteurs : | Elizabeth-M POOLE ; BAER (Heather-J) : USA. Division of General Medicine and Primary Care. Brigham and Women's Hospital. Boston. MA. ; Susan-E HANKINSON ; POLLAK (Michael-N) : CAN. Cancer Prevention Research Unit. Department of Oncology. Faculty of Medicine. McGill University. Montreal. PQ. ; Eva-S SCHERNHAMMER ; Shelley-S TWOROGER |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 174, n° 6, 2011) |
| Pagination : | 642-651 |
| Langues: | Anglais |
| Mots-clés : | Obésité ; Taille corporelle ; Adulte ; Poids naissance ; Enfant ; Croissance ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 7tR0xEGG. Diffusion soumise à autorisation]. Body size in early life has been associated with breast cancer risk. This may be partly mediated through the insulin-like growth factor (IGF) pathway. The authors assessed whether birth weight, body fatness at ages 5 and 10 years, and body mass index (BMI ; weight (kg)/height (m) 2) at age 18 years were associated with plasma concentrations of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 in 6,520 women aged 32-70 years at blood draw from the Nurses'Health Study (1990-2006) and Nurses'Health Study II (1997-2005). Birth weight, body fatness in childhood, and BMI at age 18 years were inversely associated with adult IGF-1 levels. For example, IGF-1 levels were 11.9% lower in women who reported being heaviest at age 10 years than in those who were leanest at age 10 (P-trend<0.0001). Further, women who reported their birth weight as>=10 pounds (>4.5 kg) (vs.<5.5 pounds (<2.5 kg)) had 7.9% lower IGF-1 levels (P-trend=0.002). Women whose BMI at age 18 years was>=30 (vs.<20) had 14.1% lower IGF-1 levels (P-trend<0.0001). Similar inverse associations were observed for insulin-like growth factor binding protein 3. These observations did not vary by adult BMI or meno-pausal status at blood draw. These findings suggest that altered IGF-1 levels in adulthood may be a mechanism through which early-life body size influences subsequent breast cancer risk. |
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