Résumé :
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[BDSP. Notice produite par INIST-CNRS I98DDR0x. Diffusion soumise à autorisation]. The authors evaluated indoor air pollution from coal combustion (IAPCC) as a potential risk factor for neural tube defects (NTDs) in a rural population in Shanxi Province, China. The studied rural population has both high IAPCC exposure and a high prevalence of NTDs. A population-based case-control study was used to identify 610 NTD cases and 837 normal controls between November 2002 and December 2007. Information was collected within 1 week following delivery or pregnancy termination due to prenatal NTD diagnosis. The authors derived an exposure index by integrating a series of IAPCC-related characteristics concerning dwelling and lifestyle. Compared with women with no IAPCC exposure, women with any exposure at all had a 60% increased risk of having a child with an NTD (adjusted odds ratio (OR)=1.6,95% confidence interval (CI) : 1.1,2.1). An increased NTD risk was linked to both residential heating (adjusted OR=1.7,95% CI : 1.1,2.4) and cooking (adjusted OR=1.5,95% CI : 1.1,2.1). The risk increased with increases in the exposure index, showing a dose-response trend (P<0.001). This is the first known study to link IAPCC to NTDs. Additional studies are needed to confirm the link between IAPCC and NTDs.
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