| Titre : | Inflammation Biomarkers and Risk of All-Cause Mortality in the Reasons for Geographic and Racial Differences in Stroke Cohort. (2011) |
| Auteurs : | Edmond-K KABAGAMBE ; Mary CUSHMAN ; Virginia-J HOWARD ; Matthew HSIEH ; Nancy-S JENNY ; Suzanne-E JUDD ; David-G WARNOCK ; Neil-A ZAKAI ; Department of Epidemiology. School of Public Health. University of Alabama. Birmingham. AL. USA ; Department of Medicine. College of Medicine. University of Vermont. Burlington. VT. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 174, n° 3, 2011) |
| Pagination : | 284-292 |
| Langues: | Anglais |
| Mots-clés : | Accident cérébrovasculaire ; Inflammation ; Facteur risque ; Risque ; Facteur ; Epidémiologie ; Mortalité ; Ethnie ; Race ; Etude comparée ; Leucocyte ; Etude prospective |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 9R0xADpq. Diffusion soumise à autorisation]. Inflammation biomarkers, including higher high-sensitivity C-reactive protein (hsCRP) levels, higher white blood cell (WBC) counts, and lower serum albumin levels, are associated with an increased risk of all-cause mortality. Many studies have examined these biomarkers individually, but less is known about their joint association with mortality. hsCRP, WBC count, and serum albumin were measured at baseline in the Reasons for Geographic and Racial Differences in Stroke Study cohort members, who were enrolled in 2003-2007. Over 4.5 years, there were 1,062 deaths in 17,845 participants. High-risk categories were defined as hsCRP or WBC levels above the 75th percentile (5.1 mg/L and 6.9 x 109 cells/L, respectively) and albumin levels below the 25th percentile (4.00 g/dL). The authors derived 4 groups that corresponded to 0 (n=8,341), 1 (n=6,277), 2 (n=2,635), or 3 (n=592) biomarkers in the high-risk category. After adjustment for age, sex, waist circumference, race, region, smoking, alcohol use, income, educational level, physical activity frequency, and medical history and compared with those with no biomarkers in the high-risk category, the hazard ratios for all-cause mortality for 1,2, and 3 biomarkers in the high-risk category were 1.56 (95% confidence interval : 1.33,1.82), 2.19 (95% confidence interval : 1.84,2.62), and 2.96 (95% confidence interval : 2.30,3.80), respectively (Ptrend<0.0001). Adding the 3 inflammation biomarkers to a fully adjusted model improved risk discrimination by 23.7% (95% confidence interval : 9.3,39.9). Measurement of more than 1 biomarker is more useful in risk prediction than single biomarkers. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact