| Titre : | Serum Phospholipid Fatty Acids and Prostate Cancer Risk : Results From the Prostate Cancer Prevention Trial. (2011) |
| Auteurs : | Theodore-M BRASKY ; ALBANES (Demetrius) : USA. Department of Cancer Epidemiology and Genetics. National Cancer Institute. Washington. DC. ; Phyllis GOODMAN ; KING (Irena-B) : USA. Cancer Population Sciences Research Program. University of New Mexico Cancer Center. Albuquerque. NM. ; Alan-R KRISTAL ; Marian-L NEUHOUSER ; THOMPSON (Ian-M) : USA. Department of Urology. The University of Texas Health Science Center at San Antonio. San Antonio. TX. ; Cathee TILL ; Emily White ; . XIAOLING SONG |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 173, n° 12, 2011) |
| Pagination : | 1429-1439 |
| Langues: | Anglais |
| Mots-clés : | Sérum ; Acide gras ; Facteur risque ; Risque ; Résultat ; Prévention santé ; Essai préventif ; Essai thérapeutique ; Procès ; Inflammation ; Epidémiologie ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS oR0xC77k. Diffusion soumise à autorisation]. Inflammation may be involved in prostate cancer development and progression. This study examined the associations between inflammation-related phospholipid fatty acids and the 7-year-period prevalence of prostate cancer in a nested case-control analysis of participants, aged 55-84 years, in the Prostate Cancer Prevention Trial during 1994-2003. Cases (n=1,658) were frequency matched to controls (n=1,803) on age, treatment, and prostate cancer family history. Phospholipid fatty acids were extracted from serum, and concentrations of oméga-3, oméga-6, and trans-fatty acids (TFAs) were expressed as proportions of the total. Logistic regression models estimated odds ratios and 95% confidence intervals of associations of fatty acids with prostate cancer by grade. No fatty acids were associated with low-grade prostate cancer risk. Docosahexaenoic acid was positively associated with high-grade disease (quartile 4 vs. 1 : odds ratio (OR)=2.50,95% confidence interval (CI) : 1.34,4.65) ; TFA 18 : 1 and TFA 18 : 2 were linearly and inversely associated with risk of high-grade prostate cancer (quartile 4 vs. 1 : TFA 18 : 1, OR=0.55,95% CI : 0.30,0.98 ; TFA 18 : 2, OR=0.48,95% CI : 0.27,0.84). The study findings are contrary to those expected from the pro-and antiinflammatory effects of these fatty acids and suggest a greater complexity of effects of these nutrients with regard to prostate cancer risk. |
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