| Titre : | Sun exposure and melanoma risk at different latitudes : a pooled analysis of 5700 cases and 7216 controls. (2009) |
| Auteurs : | Yu-Mei CHANG ; Bruce-K ARMSTRONG ; Jennifer-H BARRETT ; Veronique Bataille ; Wilma BERGMAN ; Marianne BERWICK ; Dtimothy BISHOP ; Paige-M BRACCI ; Jmark ELWOOD ; Marc-S ERNSTOFF ; Richard-P GALLAGHER ; Adèle-C GREEN ; Nelleke-A GRUIS ; Elizabeth-A HOLLY ; Christian INGVAR ; Peter-A KANETSKY ; Margaret-R KARAGAS ; Loic LE MARCHAND ; Tim-K LEE ; Rona-M MACKIE ; Julia-A NEWTON-BISHOP ; Hakan OLSSON ; Anne OSTERLIND ; Timothy-R REBBECK ; Peter SASIENI ; Victor SISKIND ; Anthony-J SWERDLOW ; Linda TITUS-ERNSTOFF ; Michael-S ZENS ; Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics. University of Pennsylvania. Philadelphia. PA. USA ; Department of Community and Family Medicine. Dartmouth Medical School and the Norris Cotton Cancer Center. Lebanon. NH. USA ; Department of Dermatology. Leiden University Medical Center. Leiden. NLD ; Queensland Institute of Medical Research. Po Royal Brisbane Hospital. Brisbane. AUS ; Section of Epidemiology and Biostatistics. Leeds Institute of Molecular Medicine. Leeds. GBR |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 38, n° 3, 2009) |
| Pagination : | 814-830 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Risque ; Enquête cas témoin ; Exposition professionnelle ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS JkR0x8mH. Diffusion soumise à autorisation]. Background Melanoma risk is related to sun exposure ; we have investigated risk variation by tumour site and latitude. Methods We performed a pooled analysis of 15 case-control studies (5700 melanoma cases and 7216 controls), correlating patterns of sun exposure, sunburn and solar keratoses (three studies) with melanoma risk. Pooled odds ratios (pORs) and 95% Bayesian confidence intervals (CIs) were estimated using Bayesian unconditional polytomous logistic random-coefficients models. Results Recreational sun exposure was a risk factor for melanoma on the trunk (pOR=1.7 ; 95% CI : 1.4-2.2) and limbs (pOR=1.4 ; 95% CI : 1.1-1.7), but not head and neck (pOR=1.1 ; 95% CI : 0.8-1.4), across latitudes. Occupational sun exposure was associated with risk of melanoma on the head and neck at low latitudes (pOR=1.7 ; 95% CI : 1.0-3.0). Total sun exposure was associated with increased risk of melanoma on the limbs at low latitudes (pOR=1.5 ; 95% CI : 1.0-2.2), but not at other body sites or other latitudes. The pORs for sunburn in childhood were 1.5 (95% CI : 1.3-1.7), 1.5 (95% CI : 1.3-1.7) and 1.4 (95% CI : 1.1-1.7) for melanoma on the trunk, limbs, and head and neck, respectively, showing little variation across latitudes. The presence of head and neck solar keratoses was associated with increased risk of melanoma on the head and neck (pOR=4.0 ; 95% CI : 1.7-9.1) and limbs (pOR=4.0 ; 95% CI : 1.9-8.4). Conclusion Melanoma risk at different body sites is associated with different amounts and patterns of sun exposure. Recreational sun exposure and sunburn are strong predictors of melanoma at all latitudes, whereas measures of occupational and total sun exposure appear to predict melanoma predominately at low latitudes. |
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