| Titre : | Lung function in mid-life compared with later life is a stronger predictor of arterial stiffness in men : The Caerphilly Prospective Study. (2009) |
| Auteurs : | Charlotte-E BOLTON ; Yoav BEN-SHLOMO ; John-R COCKCROFT ; Shah EBRAHIM ; John-E GALLACHER ; Carmel-M MCENIERY ; Margaret MUNNERY ; Ramsey SABIT ; Dennis-J SHALE ; Ian-B WILKINSON ; Department of Clinical Pharmacology. University of Cambridge. Addenbrooke's Hospital. Cambridge. GBR ; Department of Respiratory Medicine. School of Medicine. Cardiff University. Cardiff South Wales. GBR |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 38, n° 3, 2009) |
| Pagination : | 867-876 |
| Langues: | Anglais |
| Mots-clés : | Artériosclérose ; Etude comparée ; Homme ; Pays de Galles ; Etude prospective ; Epidémiologie ; Grande Bretagne ; Europe |
| Résumé : | [BDSP. Notice produite par INIST-CNRS nEBR0xCA. Diffusion soumise à autorisation]. Background. Increased arterial stiffness predicts future cardiovascular disease and in some cross-sectional studies it is related to worse lung function and obstructive pulmonary disease. We assessed the predictive value of lung function measured in mid-life as compared with later life on arterial stiffness in the Caerphilly Prospective Study (CaPS). Methods. Men aged 47-67 years had lung function measured between 1984 and 1988 and repeated between 2002 and 2004 (n=827) as well as having carotid-femoral pulse wave velocity (PWV) measured. Results. Both forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in mid-life and later life were inversely associated with PWV (P<0.0001) but mid-life measures were stronger predictors. Only mid-life measures remained predictors after mutual adjustment (FEV1 mid-life bêta coeff. - 0.65,95% CI - 1.04, - 0.26, P<0.0001 ; FVC mid-life bêta coeff. - 0.52,95% CI - 0.82, - 0.23, P<0.0001). Adjustment for smoking status, early life, inflammatory and metabolic factors in sub-groups did not markedly change the associations. Conclusions. Mid-life lung function is a stronger risk factor than in later life for arterial stiffness in men. It is possible that developmental factors influence both lung function and arterial stiffness. Lung function assessment in mid-life may identify individuals at greater risk of their future cardiovascular disease. |
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