| Titre : | Association of Diabetes With Prostate Cancer Risk in the Multiethnic Cohort. (2009) |
| Auteurs : | Kevin-M WATERS ; Christopher-A HAIMAN ; Brian-E HENDERSON ; KOLONEL (Laurence-N) : USA. Epidemiology Program. Cancer Research Center. University of Hawaii. Honolulu. HI. ; Daniel-O STRAM ; Peggy WAN ; Department of Preventive Medicine. Keck School of Medicine. University of Southern California. Norris Comprehensive Cancer Center. Los Angeles. CA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 169, n° 8, 2009) |
| Pagination : | 937-945 |
| Langues: | Anglais |
| Mots-clés : | Diabète ; Risque cumulé ; Facteur associé ; Association ; Facteur risque ; Risque ; Ethnie ; Ethnologie ; Prostate ; Epidémiologie ; Homme ; Cancer ; Glande endocrine [pathologie] ; Appareil urogénital |
| Résumé : | [BDSP. Notice produite par INIST-CNRS kt8AR0xs. Diffusion soumise à autorisation]. Among men of European ancestry, diabetics have a lower risk of prostate cancer than do nondiabetics. The biologic basis of this association is unknown. The authors have examined whether the association is robust across populations in a population-based prospective study. The analysis included 5,941 prostate cancer cases identified over a 12-year period (1993-2005) among 86,303 European-American, African-American, Latino, Japanese-American, and Native Hawaiian men from the Multiethnic Cohort. The association between diabetes and prostate-specific antigen (PSA) levels (n=2,874) and PSA screening frequencies (n=46,970) was also examined. Diabetics had significantly lower risk of prostate cancer than did nondiabetics (relative risk=0.81,95% confidence interval (Cl) : 0.74,0.87 ; P<0.001), with relative risks ranging from 0.65 (95% Cl : 0.50,0.84 ; P=0.001) among European Americans to 0.89 (95% Cl : 0.77,1.03 ; P=0.13) among African Americans. Mean PSA levels were significantly lower in diabetics than in nondiabetics (mean PSA levels, 1.07 and 1.28, respectively ; P=0.003) as were PSA screening frequencies (44.7% vs. 48.6% ; P<0.001) ; however, this difference could explain only a small portion (approximately 20%) of the inverse association between these diseases. Diabetes is a protective factor for prostate cancer across populations, suggesting shared risk factors that influence a common mechanism. |
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