| Titre : | Association of blood lactate with type 2 diabetes : the Atherosclerosis Risk in Communities Carotid MRI Study. (2010) |
| Auteurs : | Stephen-O CRAWFORD ; Brad-C ASTOR ; Christie-M BALLANTYNE ; Frederick-L BRANCATI ; Ron-C HOOGEVEEN ; Jeffery HUNTER YOUNG ; SCHMIDT (Maria-Ines) : BRA. Graduate Studies Program in Epidemiology. School of Medicine. Federal University of Rio Grande do Sul. Porto Alegre. ; Center for Cardiovascular Disease Prevention. Methodist DeBakey Heart Center. Houston. TX. USA ; Section of Atherosclerosis and Vascular Medicine. Department of Medicine. Baylor College of Medicine. Houston. TX. USA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 39, n° 6, 2010) |
| Pagination : | 1647-1655 |
| Langues: | Anglais |
| Mots-clés : | Homme ; Sang ; Facteur risque ; Epidémiologie ; Insuline ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xG8888. Diffusion soumise à autorisation]. Background Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies. Methods To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. Results The prevalence of type 2 diabetes rose across lactate quartiles (11,14,20 and 30% ; P for trend<0.0001). Following adjustment for demographic factors, physical activity, body mass index and waist circumference, the relative odds of type 2 diabetes across lactate quartiles were 0.98 [95% confidence interval (CI) 0.59-1.64], 1.64 (95% CI 1.03-2.64) and 2.23 (95% CI 1.38-3.59), respectively. Furthermore, lactate was associated with higher fasting glucose among non-diabetic adults. Conclusions Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk. |
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