| Titre : | Use of A Mendelian Randomization Approach to Assess the Causal Relation of gamma-Glutamyltransferase with Blood Pressure and Serum Insulin Levels. (2010) |
| Auteurs : | CONEN (David) : CHE. Department of Medicine. University Hospital Basel. Basel. ; Murielle BOCHUD ; Pedro MARQUES-VIDAL ; Fred PACCAUD ; Valentin ROUSSON ; Peter VOLLENWEIDER ; Gérard WAEBER ; Department of Medicine. Centre Hospitalier Universitaire Vaudois and University of Lausanne. Lausanne. CHE ; Institute of Social and Preventive Medicine. Centre Hospitalier Universitaire Vaudois and University of Lausanne. Lausanne. CHE |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 172, n° 12, 2010) |
| Pagination : | 1431-1441 |
| Langues: | Anglais |
| Mots-clés : | Diabète ; Obésité ; Utilisation ; Randomisation ; Facteur ; Pression artérielle ; Insuline ; Epidémiologie ; Enzyme ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xJDmH9. Diffusion soumise à autorisation]. Elevated levels of gamma-glutamyltransferase (GGT) have been associated with elevated blood pressure (BP) and diabetes. However, the causality of these relations has not been addressed. The authors performed a cross-sectional analysis (2003-2006) among 4,360 participants from the population-based Cohorte Lausannoise (CoLaus) Study (Lausanne, Switzerland). The rs2017869 variant of the gamma-glutamyltransferase 1 (GGT1) gene, which explained 1.6% of the variance in GGT levels, was used as an instrument for Mendelian randomization (MR). Sex-specific GGT quartiles were strongly associated with both systolic and diastolic BP (all P's<0.0001). After multivariable adjustment, these relations were attenuated but remained significant. Using MR, the authors observed no positive association of GGT with BP (systolic : bêta - 5.68,95% confidence interval (CI) : - 11.51,0.16 (P=0.06) ; diastolic : bêta=-2.24,95% CI : - 5.98,1.49 (P=0.24)). The association of GGT with insulin was also attenuated after multivariable adjustment but persisted in the fully adjusted model (bêta=0.07,95% CI : 0.04,0.09 ; P<0.0001). Using MR, the authors also observed a positive association of GGT with insulin (bêta=0.19,95% CI : 0.01,0.37 ; P=0.04). In conclusion, the authors found evidence for a direct causal relation of GGT with fasting insulin but not with BP. |
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