| Titre : | Endogenous testosterone and the prospective association with carotid atherosclerosis in men : the Tromso study. (2009) |
| Auteurs : | T. VIKAN ; JOHNSEN (S.H.) : NOR. Department of Neurology. University Hospital of North Norway. Tromso. ; I. NJOLSTAD ; SCHIRMER (H.) : NOR. Department of Cardiology. University Hospital of North Norway. Tromso. ; SVARTBERG (J.) : NOR. Department of Medicine. University Hospital of North Norway. Tromso. ; Institute of Clinical Medicine. University of Tromso. Tromso. NOR |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 24, n° 6, 2009) |
| Pagination : | 289-295 |
| Langues: | Anglais |
| Mots-clés : | Etude prospective ; Artériosclérose ; Association ; Homme ; Norvège ; Epidémiologie ; Europe ; Appareil cardiovasculaire ; Artère ; Vaisseau |
| Résumé : | [BDSP. Notice produite par INIST-CNRS nr8R0xqs. Diffusion soumise à autorisation]. The role of testosterone in the development of cardiovascular disease is controversial. Recent observational studies, however, suggest a protective role of normal endogenous testosterone levels in the development of atherosclerosis. In a cohort from the Tromso study, 1,101 men had both hormone-levels measured and the right carotid artery examined by ultrasound in 1994 and 2001. We studied the prospective association between sex hormone-levels and progression of carotid intima-media thickness (IMT) and plaque area from 1994 to 2001. We also performed a cross-sectional study of 2,290 men from the population in 2001. The data were analysed by univariate correlations, analyses of covariance and multiple linear regression analyses. In the cross-sectional study, we found an inverse association between testosterone levels and total carotid plaque area (P<0.05), after adjusting for age, systolic blood pressure, smoking and use of lipid-lowering drugs. We found no prospective associations between sex hormone-levels and change in plaque area or IMT from 1994 to 2001. The lack of prospective associations in our study may be due to increased use of anti-hypertensive and lipid-lowering drugs from 1994 baseline to follow-up. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact