| Titre : | The Sonoma Water Evaluation Trial : A Randomized Drinking Water Intervention Trial to Reduce Gastrointestinal Illness in Older Adults. (2009) |
| Auteurs : | John-Mjr COLFORD ; Benjamin-F Arnold ; Joseph-Ns EISENBERG ; HILTON (Joan-F) : USA. Department of Epidemiology and Biostatistics. University of California. San Francisco. ; Sona SAHA ; James SCOTT ; WADE (Timothy-J) : USA. United States Environmental Protection Agency. Chapel Hill. NC. ; Catherine-C WRIGHT |
| Type de document : | Article |
| Dans : | American journal of public health (vol. 99, n° 11, 2009) |
| Pagination : | 1988-1995 |
| Langues: | Anglais |
| Mots-clés : | Eau consommation humaine ; Evaluation ; Essai thérapeutique ; Randomisation ; Personne âgée ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS nkR0xHEr. Diffusion soumise à autorisation]. Objectives. We estimated the relative rate of highly credible gastrointestinal illness (HCGI) per year associated with active versus sham household water filtration devices among older adults in a community receiving tap water meeting current US standards. Methods. We conducted a randomized, triple-blinded, crossover trial in 714 households (988 individuals), which used active and sham water filtration devices for 6 months each. We estimated the annual incidence rate ratio of HCGI episodes and the longitudinal prevalence ratio of HCGI days at population and individual levels with a generalized estimating equation (GEE) and generalized linear mixed models (GLMMs), respectively, adjusted for covariates associated with outcome. Results. The incidence rate ratios (active versus sham) were 0.88 (95% confidence interval [CI]=0.77,1.00) and 0.85 (95% CI=0.76,0.94) HCGI episodes per year estimated by GEE and GLMM models, respectively. The corresponding longitudinal prevalence ratios were 0.88 (95% CI=0.74,1.05) and 0.84 (95% CI=0.78,0.90) HCGI days per person per year. Conclusions. We observed reductions in population-and individual-level measures of HCGI associated with use of the active filtration device. These findings suggest the need for further research on the impact of drinking water on the health of sensitive subpopulations. |
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